Universal reference book for medicines
Product name: ORNISID (ORNISID)

Active substance: ornidazole

Type: Antiprotozoal preparation with antibacterial activity

VE TIC. (Turkey)
Composition, form of production and packaging
The tablets covered with a cover of
white or almost white color, round, biconcave, with risk on one side.

1 tab.

Ornidazole 250 mg

Excipients: hydroxymethylethylcellulose, potato starch, magnesium stearate, microcrystalline cellulose.

Composition of the membrane: hypromellose, talc, titanium dioxide.

10 pieces.
- blisters (2) - packs of cardboard.
Orniside Forte

The tablets covered with a cover of white or almost white color, round, biconcave, with risk on one side.

1 tab.

Ornidazole 500 mg

Excipients: hypromellose, microcrystalline cellulose, potato starch, magnesium stearate.

Sheath composition: hydroxymethylethylcellulose, carbovascus 4000, methylene chloride, methanol, Opaspry white.

10 pieces.
- blisters (1) - packs of cardboard.

The product description was approved by the manufacturer for the 2009 print edition.


Antiprotozoal preparation with antibacterial activity.

The mechanism of action is the biochemical reduction of the 5-nitro group of ornidazole by intracellular transport proteins of anaerobic microorganisms and protozoa.The reduced 5-nitro group of ornidazole reacts with the DNA of a cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.

It is active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia spp .;
obligate anaerobic microorganisms:Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonela spp., Prevotella bivia, Prevotella buccae, Prevotella disiens; Gram-positive microorganisms: Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp., Mobiluncus spp.
The preparation is not sensitive to aerobic microorganisms.



After oral administration, it is well absorbed from the digestive tract.
Bioavailability is 90%. The time to reach C max is 1-2 h.

Binding to plasma proteins - not less than 15%.
Penetrates through the BBB.
Metabolism and excretion

Metabolized in the liver by hydroxylation, oxidation and glucuronation.

It is excreted in the form of metabolites with urine (60-80%) and feces (20-25%).
About 5% is displayed unchanged. T 1/2 is about 13 hours.

- Trichomoniasis;

- amebiasis, amoebic dysentery, extraintestinal amoebiasis (including amoebic liver abscess);

- giardiasis;

- prevention of infections caused by anaerobic bacteria, in operations on the colon and in gynecology.


With trichomoniasis, adults are prescribed 500 mg 2 times / day for 5 days.
Children dose is set at the rate of 25 mg / kg body weight 1 time / day once.
In infections caused by anaerobes, - 500 mg every 12 hours.

With amoebic dysentery, adults and children weighing more than 35 kg are prescribed 1.5 g once a day, with a body weight of more than 60 kg - 2 g / day.Children with body weight less than 35 kg daily dose is set at the rate of 40 mg / kg body weight.
The course of treatment is 3 days.
In other forms of amebiasis, adults and children over the age of 12 years - 500 mg, children aged 7 to 12 years - 375 mg, at the age of 1 to 6 years - 250 mg, up to 1 year - 125 mg.
Multiplicity of the appointment 2 times / day (morning and evening); the duration of therapy is 5-10 days.
With giardiasis, adults and children weighing more than 35 kg - 1.5 grams 1 time / day, children weighing less than 35 kg - 40 mg / kg / day.
The duration of therapy is 1-2 days.
To prevent infections caused by anaerobic bacteria , appoint 0.5-1 g before the operation and 0.5 g 2 times / day after the operation for 3-5 days.


From the side of the central nervous system and the peripheral nervous system: headache, dizziness, impaired consciousness, tremor, stiffness, discoordination of movements, convulsions, sensory or mixed peripheral neuropathy.

From the digestive system: nausea, vomiting, diarrhea.


- organic diseases of the central nervous system;

- I trimester of pregnancy;

- the period of lactation (breastfeeding);

- hypersensitivity to the components of the drug;

- hypersensitivity to nitroimidazole derivatives.


The drug is contraindicated in the first trimester of pregnancy and during breastfeeding.


In the treatment of trichomoniasis, simultaneous treatment of both sex partners should be carried out.


Symptoms: epileptiform cramps, depression, peripheral neuritis.

Treatment: conduct symptomatic therapy;
when cramps are prescribed diazepam.

With simultaneous application of Ornisid enhances the effect of anticoagulants coumarinic series.

Ornisid prolongs the miorelaksiruyuschee action of vecuronium bromide.

When used simultaneously with ethanol, it does not inhibit acetaldehyde dehydrogenase.


The drug is released by prescription.


The drug should be stored out of reach of children at a temperature of no higher than 30 ° C.
Shelf life - 2 years.
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