Universal reference book for medicines

Active substance: tamsulosin

Type: A drug used for urination disorders associated with benign prostatic hyperplasia.
Alpha 1- adrenoblocker
Manufacturer: RANBAXY LABORATORIES (India)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

The blocker?
1- adrenoreceptors; a remedy for symptomatic treatment of benign prostatic hyperplasia.
Selectively block postsynaptic?
1A- adrenoreceptors of smooth muscles of the prostate gland, the neck of the bladder, the prostatic part of the urethra. As a result, the tone of the smooth muscles of these formations decreases, and the outflow of urine is facilitated. Simultaneously, the symptoms of obstruction and irritation associated with benign prostatic hyperplasia decrease. The therapeutic effect is manifested approximately 2 weeks after the start of treatment.
Is much less expressed in tamsulosin the ability to block?
1B- adrenoreceptors of smooth muscle vessels, so the effect on systemic blood pressure is negligible.
After ingestion, tamsulosin is rapidly and almost completely absorbed from the digestive tract.
After a single intake of 400 μg C max of the active substance in the plasma is achieved after 6 hours.
Binding to plasma proteins - 99%.
V d is negligible and is 0.2 l / kg.
Tamsulosin is slowly metabolized in the liver with the formation of pharmacologically active metabolites, which retain high selectivity to?
1A- adrenoreceptors. Most of the active substance is present in the blood in unchanged form.
T 1/2 tamsulosin at a single admission - 10 h, terminal T 1/2 is - 22 h. It is excreted by the kidneys, 9% - unchanged.

Benign prostatic hyperplasia.

Inside - 400 mcg 1 time / day (after breakfast).

From the cardiovascular system: rarely - dizziness, orthostatic hypotension, a feeling of palpitations.

From the side of the central nervous system: there may be a headache, asthenia.

On the part of the reproductive system: rarely - retrograde ejaculation.

Hypersensitivity to tamsulosin.

In patients with impaired renal function, a change in the dosing regimen is not required.

Use with caution in patients with severe violations of liver function.

With caution apply in patients prone to arterial hypotension, with severe violations of liver function.

Before starting therapy with tamsulosin, the patient should be examined for other diseases that can cause the same symptoms as benign prostatic hyperplasia.
Before the beginning of treatment and regularly during therapy, a digital rectal examination and, if required, the determination of a specific antigen of the prostate should be performed. In patients with impaired renal function, a change in the dosing regimen is not required.
Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

With the simultaneous use of tamsulosin with cimetidine, a slight increase in the concentration of tamsulosin in the blood plasma was noted, and with furosemide a decrease in concentration was noted;
with others ? 1- adrenoblockers - a marked increase in the hypotensive effect is possible.
Diclofenac and indirect anticoagulants slightly increase the rate of elimination of tamsulosin.

Diazepam, propranolol, trichloromethiazide, chloromadinone, amitriptyline, diclofenac, glibenclamide, simvastatin and warfarin do not change the free tamsulosin fraction in human plasma in vitro.
In turn, tamsulosin also does not change the free fractions of diazepam, propranolol, trichloromethiazide and chloromadinone.
In studies in vitro, no interaction was found at the level of hepatic metabolism with amitriptyline, salbutamol, glibenclamide, and finasteride.

1- adrenoblockers, acetylcholinesterase inhibitors, alprostadil, anesthetics, diuretics, levodopa, antidepressants, beta adrenoblockers, slow calcium channel blockers, muscle relaxants, nitrates and ethanol can increase the intensity of the hypotensive effect.
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