Universal reference book for medicines
Name of the drug: ORVITOL NP (ORVITOL NP)

Active substance: nonappropriate

Type: Antiviral drug

The manufacturer: NATUR PRODUKT EUROPE (Netherlands) is produced by H.TEN HERKEL BV (Netherlands), which issues quality control NATUR PRODUKT EUROPE (Netherlands)
Composition, form of production and packaging
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Capsules colorless transparent №3. The contents of capsules are white powder with a shade from cream to grayish-beige.
1 caps.

6-Bromo-5-hydroxy-1-methyl-4-dimethylaminomethyl-2-phenylthiomethylindole-3-carboxylic acid hydrochloride monohydrate hydrochloride (umifenovir) 50 mg

Excipients: calcium hydrophosphate dihydrate 9.275 mg, magnesium stearate 1.3 mg, microcrystalline cellulose 56.625 g, silicon dioxide colloid 1.05 mg.

10 pieces.
- PVC blisters / Aluminum (1) - packs of cardboard.
10 pieces.
- PVC blisters / Aluminum (2) - cardboard packs.
10 pieces.
- PVC blisters / Aluminum (3) - cardboard packs.
10 pieces.
- PVC blisters / Aluminum (4) - cardboard packs.
?
Capsules colorless transparent №1. The contents of capsules are white powder with a shade from cream to grayish-beige.
1 caps.

6-bromo-5-hydroxy-1-methyl-4-dimethylaminomethyl-2-phenylthiomethylindole-3-carboxylic acid hydrochloride hydrochloride monohydrate (umifenovir) 100 mg

Excipients: calcium hydrophosphate dihydrate 18.445 mg, magnesium stearate 2.615 mg, microcrystalline cellulose 113.245 g, silicon dioxide colloid 2.095 mg.

10 pieces.
- PVC blisters / Aluminum (1) - packs of cardboard.
10 pieces.
- PVC blisters / Aluminum (2) - cardboard packs.
10 pieces.
- PVC blisters / Aluminum (3) - cardboard packs.
10 pieces.
- PVC blisters / Aluminum (4) - cardboard packs.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

An antiviral agent, has an immunomodulatory and anti-influenza action, specifically suppresses influenza A and B viruses, severe acute respiratory syndrome (SARS).

The antiviral effect is due to the suppression of the fusion of the lipid envelope of the virus with the cell membranes upon contact of the virus with the cell.

Has interferon-inducing properties, stimulates humoral and cellular immunity reactions, phagocytic function of macrophages, increases the body's resistance to viral infections.

Therapeutic efficacy, due to the suppression of influenza viruses and ARVI, is manifested in a decrease in the severity of intoxication and catarrhal phenomena, the period of fever and the overall duration of the disease.

It prevents the development of post-influenza complications, reduces the frequency of exacerbations of chronic bacterial diseases.

PHARMACOKINETICS

Absorption is fast.
Quickly distributed to organs and tissues. TC max when taken in a dose of 50 mg -1.2 h, 100 mg - 1.5 hours Metabolized in the liver. T 1/2 17-21 hours. About 40% is excreted unchanged, mainly through the intestine (38.9%) and in an insignificant amount by the kidneys (0.12%). During the first day, 90% of the administered dose is withdrawn.
INDICATIONS

Prevention and treatment in adults and children:

- influenza A and B, ARVI (including complicated by bronchitis, pneumonia);
secondary immunodeficiency states, severe acute respiratory syndrome (SARS);
- complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infection;

- prevention of postoperative infectious complications and normalization of immune status in adults;

- in the complex therapy of acute intestinal infections of rotavirus etiology in children older than 3 years (50 mg) and children over 6 years (100 mg).

DOSING MODE

Inside, before eating.

For nonspecific prophylaxis:

- with direct contact with patients with influenza and other ARVI: children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg once a day for 10-14 days;

- during the epidemic of influenza and other acute respiratory infections, to prevent exacerbations of chronic bronchitis, recurrence of herpetic infection: children from 3 to 6 years - 50 mg, from 6 to 12 years -100 mg, over 12 years and adults - 200 mg 2 times a week within 3 weeks.

For treatment:

- flu, other acute respiratory infections without complications: children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 4 times a day (every 6 hours) for 5 days;

- influenza, other acute respiratory infections with complications (bronchitis, pneumonia, etc.): children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg,over 12 years and adults - 200 mg 3 times a day for 5 days, then a single dose once a week for 3-4 weeks.

In the complex therapy of chronic bronchitis, herpetic infection: children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 3 times a day for 5 days, then a single dose 2 times per week for 3-4 weeks.

Prevention of postoperative complications: adults - 200 mg for 2 days before the operation, then 200 mg for 2 and 5 days after the operation.

In the complex therapy of acute intestinal infections of rotavirus etiology, children over 12 years and adults are prescribed 200 mg 4 times a day (every 6 hours) for 5 days, at the age of 6 to 12 years - 100 mg 4 times a day (every 6 hours) for 5 days, at the age of 3 to 6 years - 50 mg 4 times a day (every 6 hours) for 5 days.

SIDE EFFECT

Rarely allergic reactions.

CONTRAINDICATIONS

- Children's age (up to 3 years);

- pregnancy and lactation;

hypersensitivity.

PREGNANCY AND LACTATION

Contraindicated during pregnancy and lactation.

APPLICATION FOR CHILDREN

Contraindicated in children under 3 years.

SPECIAL INSTRUCTIONS

Does not show central neurotropic activity, taking the drug does not affect the ability to drive vehicles and engage in other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

DRUG INTERACTION

When prescribed with other drugs, no negative effects were observed.

TERMS OF RELEASE FROM PHARMACY

Without recipe.

TERMS AND CONDITIONS OF STORAGE

At a temperature of no higher than 25 ° C.
Keep out of the reach of children! Shelf life - 3 years.
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