Universal reference book for medicines
Product name: ONCODOCEL

Active substance: docetaxel

Type: Antitumor preparation

Manufacturer: TOLMAR (Panama) manufactured by FARMACEUTICA PARAGUAYA (Paraguay)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
An antineoplastic agent, a semi-synthetic analogue of paclitaxel.
The mechanism of action is associated with the accumulation of tubulin in the microtubules of the mitotic spindle, which leads to disruption in the processes of their assembly and disassembly. It disrupts the cell division in the G 2 and M phases of the cell cycle.
PHARMACOKINETICS
After a single IV injection at a dose of 100 mg / m 2, the average C max of docetaxel in plasma is 3.7 μg / ml.
The average value of V d in the equilibrium state is 113 liters. Binding to plasma proteins - 90%. Docetaxel is metabolized.
The average system clearance is 21 l / h / m 2 .
About 6% is excreted by the kidneys and 75% by the intestine, mainly in the form of metabolites and, only a small part - unchanged.
INDICATIONS
As a means of line 1 for breast cancer, as well as ineffective therapy with anthracycline-based drugs;
non-small cell lung cancer (including with ineffectiveness of other antitumour agents); malignant tumors of the head and neck; ovarian cancer.
DOSING MODE
Established individually, depending on the indications and stage of the disease, the state of the hematopoiesis system, the scheme of antitumor therapy.

SIDE EFFECT
On the part of the hematopoiesis system: neutropenia, thrombocytopenia, anemia.

On the part of the digestive system: nausea, vomiting, diarrhea, increased levels of transaminases and bilirubin in the serum;
rarely - stomatitis.
From the nervous system: paresthesia, hyperesthesia.

From the musculoskeletal system: arthralgia, myalgia.

Allergic reactions: skin manifestations are possible;
rarely - bronchospasm.
Dermatological reactions: skin rash, mainly in the area of ​​the feet, palms, and also in the upper limbs, face, chest, often accompanied by itching, sometimes followed by desquamation;
hypo- or hyperpigmentation of nails and onycholysis; alopecia.
From the side of water-electrolyte metabolism: fluid retention in the body, incl.
ascites, peripheral edema.
From the side of the cardiovascular system: arterial hypotension, disturbances of the heart rhythm.

CONTRAINDICATIONS
Neutropenia is less than 1500 / mkl, increased sensitivity to docetaxel in the anamnesis, pregnancy, lactation.

PREGNANCY AND LACTATION
Contraindicated in pregnancy and lactation.

Women of childbearing age should apply reliable methods of contraception against the background of docetaxel therapy.

SPECIAL INSTRUCTIONS
Docetaxel is not used when the bilirubin content is more than IGN in combination with the activity of hepatic transaminases, which exceeds the IGN by 1.5 times, and the AF of 2.5 times higher than the VGN.

Before starting therapy, patients are prescribed SCS inside.
The likelihood of developing allergic reactions and the occurrence of edema is significantly increased in patients who have not previously been given such therapy.
During the period of treatment, a systematic control of the peripheral blood pattern is necessary in order to detect the degree of myelodepression.

DRUG INTERACTION
Clinical data on the drug interaction of docetaxel are limited.

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