Universal reference book for medicines
Product name: ONDASOL

Active substance: ondansetron

Type: Antiemetic medication of central action blocking serotonin receptors

Manufacturer: FARMSTANDART-UFIM VITAMIN FACTORY (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Antiemetic means.
Effectively prevents and eliminates nausea and vomiting that occur against the background of antitumor chemotherapy or radiation therapy, as well as in the postoperative period. The mechanism of action is due to the ability of ondansetron to selectively block serotonin 5-HT 3 -receptors. It is believed that in the occurrence of nausea and vomiting in the course of antitumor therapy, an important role is played by the stimulation of the afferent fibers of the vagus nerve with serotonin released from the enterochromaffin cells of the gastrointestinal mucosa. Blocking 5-HT 3 -receptors, ondansetron prevents the occurrence of an emetic reflex. In addition, ondansetron depresses the central parts of the gag reflex by blocking 5-HT 3 -receptors of the bottom of the IV ventricle (area postrema).
PHARMACOKINETICS
After oral administration, ondansetron is well absorbed from the digestive tract.
Exposed to the effect of "first passage" through the liver. Binding to proteins is high (70-76%). Biotransformiruetsya in the liver, mainly by hydroxylation. Mean T 1/2 in adult patients is about 4 hours. If there is a violation of liver function, an increase in T 1/2 is noted.
INDICATIONS
Prevention of nausea and vomiting during antitumor chemo- or radiation therapy;
prevention and treatment of nausea and vomiting in the postoperative period.
DOSING MODE
Individual, depending on the indications and treatment regimen.

SIDE EFFECT
From the side of the central nervous system: headaches;
rarely - transient visual impairment and dizziness (with rapid on / in the introduction), involuntary movements.
From the cardiovascular system: rarely - chest pain, arrhythmias, bradycardia, arterial hypotension.

From the digestive system: constipation, diarrhea, abdominal pain, transient increase in the level of transaminases in the serum.

Allergic reactions: rarely - bronchospasm, angioedema, urticaria;
in some cases - anaphylactic reactions.
Other: sensation of heat and a rush of blood to the head and epigastric region.

CONTRAINDICATIONS
I trimester of pregnancy, hypersensitivity to ondansetron.

PREGNANCY AND LACTATION
Ondansetron is contraindicated for use in the first trimester of pregnancy.
If necessary, use during lactation should stop breastfeeding.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
When used in patients with moderate and severe impairment, liver function is not recommended to exceed the dose of 8 mg / day.

SPECIAL INSTRUCTIONS
When used in patients with moderate and severe impairment, liver function is not recommended to exceed the dose of 8 mg / day.

With care use ondansetron during surgical interventions on the abdominal cavity, tk.
its use can mask progressive intestinal obstruction.
DRUG INTERACTION
Due to the fact that ondansetron is metabolized in the liver by isoenzymes of the cytochrome P450 system, while simultaneous use with drugs that are inducers or inhibitors of this enzyme system, changes in clearance and T 1/2 ondansetron are possible.

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