Universal reference book for medicines
Product name: OFTAN ® CATACHROM (OFTAN ® CATACHROM)

Active substance: adenosine, cytochrom C, nicotinamide

Type: Cataract preparation

Manufacturer: SANTEN (Finland)
Composition, form of production and packaging
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Drops of the eye in the form of a transparent solution of red color.
1 ml

cytochrome C 675 μg

adenosine 2 mg

nicotinamide 20 mg

Excipients: benzalkonium chloride, sodium succinate hexahydrate, sorbitol, sodium dihydrogen phosphate dihydrate, sodium hydrogen phosphate dihydrate, water d / and.

10 ml - polyethylene bottles with lid-dropper (1) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2015.

PHARMACHOLOGIC EFFECT

Combined drug that improves the energy metabolism of the lens.

Cytochrome C plays an important role in biochemical oxidation-reduction processes in the tissues of the eyeball and is an antioxidant.

Adenosine, the precursor of ATP, takes part in the metabolic processes of the lens.

Nicotinamide stimulates the synthesis of nicotinamide-dinucleotide, cofactor dehydrogenases.

PHARMACOKINETICS

Suction and distribution

When topical application of cytochrome C is not absorbed into the systemic circulation.

Adenosine penetrates well through the cornea.

Metabolism and excretion

Cytochrome C is completely metabolized in the body in the same ways as amino acids, and gem is broken down to bilirubin, which is excreted in bile.

Adenosine is metabolized practically in all tissues with the formation of inosine, xanthine and urate, which are excreted in the urine.
Ribose, which is part of the adenosine molecule, is metabolized to glyceraldehyde-3-phosphate, and then to pyruvate, and finally cleaved in the Krebs cycle. T 1/2 adenosine from plasma is less than 1 min.
Nicotinamide is partially metabolized to nicotinic acid.
Both compounds are methylated to form N-methyl nicotinamide, which is further cleaved in the liver.Unchanged nicotinamide and metabolites are excreted in the urine.
INDICATIONS

- Cataract of different genesis.

DOSING MODE

Assign 1-2 drops to the conjunctival sac 3 times / day.

When using the vial for the first time, turn the lid of the vial down while pressing down and then open the vial.

SIDE EFFECT

From the side of the organ of vision: a brief sensation of burning and tingling of the eyes, allergic conjunctivitis, contact dermatitis.

Systemic reactions: extremely rare - short-term nausea, arterial hypotension, dizziness, dyspnea;
sensation of heat and pulsation in the temples, fainting (due to the vasodilating action of nicotinic acid).
CONTRAINDICATIONS

- Children and adolescents under 18 years of age (due to the lack of data on the effectiveness and safety of the drug in children and adolescents);

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

There is insufficient experience in the use of Ophthal ® Kathahrom in pregnancy and lactation (breastfeeding).

It is possible to use Ophtan® Catachrome during pregnancy and lactation as prescribed by the doctor and when the expected benefit of therapy for the mother exceeds the potential risk to the fetus or infant.

APPLICATION FOR CHILDREN

Contraindicated in children and adolescents under 18 years (due to the lack of data on the effectiveness and safety of the drug in children and adolescents).

SPECIAL INSTRUCTIONS

During the period of treatment with Oftan ® Catachrome, do not wear soft contact lenses.
the preservative can be deposited in them and have an adverse effect on the tissues of the eye. Before applying Oftan® Kathamroch, contact lenses should be removed and re-installed after 15 minutes after instillation of the drug.
Impact on the ability to drive vehicles and manage mechanisms

Patients who, after instillation of the drug, have a short-term eye irritation, should avoid driving vehicles, working with machinery, machines or some other equipment requiring good visual acuity, immediately after the application of eye drops.

OVERDOSE

There is no evidence of an overdose of Oftan ® by Katachrom.

DRUG INTERACTION

There was no clinically significant interaction between Ophthal® and Catachrome with other drugs.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

List B. The drug should be stored out of reach of children at a temperature of 8 ° to 15 ° C.
Shelf life - 3 years.
After opening the bottle-dropper, eye drops should be used within 1 month.

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