Universal reference book for medicines

Active substance: oxytocin

Type: Tonicity and contractile activity of myometrium

Manufacturer: GRINDEX (Latvia)
Composition, form of production and packaging
The solution for intravenous and / or injection is
clear, colorless, with a characteristic odor.

1 ml

oxytocin 5 IU

Excipients: chlorobutanol hemihydrate 5 mg / ml, acetic acid 1M to pH 3.5-4.5, water d / and up to 1 ml.

1 ml - ampoules (5) - packings the cellular contour (2) - packs cardboard.


Description of the drug approved by the manufacturer for the printed edition of 2011.


Oxytocin, a synthetic analogue of the peptide hormone of the posterior lobe of the pituitary gland, stimulates the contraction of the smooth muscles of the uterus (especially at the end of pregnancy, during labor and at the time of delivery), and myoepithelial cells in the mammary gland.
Oxytocin has a weak antidiuretic effect and in therapeutic doses does not significantly affect blood pressure. The effect occurs in 1-2 minutes with n / k and / m introduction, lasts 20-30 minutes; when in / in the introduction - after 0.5-1 minutes.

T 1/2 - 1-6 min (decreased in late pregnancy and during lactation).
The connection with plasma proteins is low (30%).
Metabolised in the liver and kidneys.
During pregnancy in plasma, target organs and in the placenta, the concentration of oxytocinase inactivating the endogenous and exogenous oxytocin increases. Excretion, mainly by the kidneys in unchanged form.

For the initiation and stimulation of labor (primary and secondary weakness of labor, the need for early delivery in connection with gestosis, rhesus-conflict, intrauterine fetal death, a delayed pregnancy, premature discharge of amniotic fluid, management of births in pelvic presentation).
For the prevention and treatment of hypotonic uterine bleeding after abortion (including for long periods of pregnancy), in the early postpartum period and to accelerate the postpartum involution of the uterus; to enhance the contractile capacity of the uterus in cesarean section (after removal of the afterbirth).

Oxytocin is administered iv in / m, into the wall or vaginal part of the cervix.
To initiate delivery, 0.5-2.0 ME of oxytocin is administered; if necessary, repeat the injection every 30-60 minutes.
For IV injection drop 1 ml of oxytocin (5 ME) in 500 ml of a 5% solution of dextrose.
Introduction begins with 5-8 drops per minute, with a subsequent increase in speed, depending on the nature of labor, but not more than 40 drops per minute. During the infusion, constant monitoring of uterine activity and fetal heart rate is necessary.
Treatment of unavoidable or incomplete abortion - iv drip, 10 IU of oxytocin per 500 ml of 5% dextrose solution at a rate of 20-40 cap / min.
For prophylaxis of hypotonic uterine bleeding, oxytocin is administered in / m 3-5 ME 2-3 times a day daily for 2-3 days, admissible in / m administration of 10 ME immediately after placenta separation.
To treat hypotonic uterine bleeding, oxytocin is administered 5-8 IU 2-3 times a day for 3 days.
If necessary, inject iv infusion of 10-40 ME oxytocin, dissolved in 100 ml of donor blood. In the operation of cesarean section (after removal of the afterbirth) Oxytocin Grindeks is injected into the uterine wall at a dose of 3-5 ME.

Possible arrhythmia and bradycardia (in the mother and fetus), a decrease or increase in blood pressure, shock, subarachnoidal bleeding, nausea, vomiting, neonatal jaundice, reduced fibrinogen concentration in the fetus, allergic reactions, bronchospasm, water retention.
If symptoms of these complications appear, discontinue the drug immediately.

Hypersensitivity, hypertension, renal insufficiency, predisposition to rupture of the uterus, mismatch in the pelvis of the mother and fetus (narrow pelvis anatomical and clinical), transverse or oblique fetal position, premature birth, threatening rupture of the uterus, scars on the uterus (after a previous cesarean section, surgery on the uterus), excessive stretching of the uterus, uterus after multiple births, uterine sepsis, invasive cervical carcinoma, uterine hypertension (not arisen during labor), fetal compression, parts
Noah placenta previa, fetal presentation facial.

Contraindicated in renal failure.


Apply only under the supervision of a doctor in a hospital under the control of the contractile activity of the uterus, the condition of the fetus, blood pressure and the general condition of the woman.


Symptoms: hyperstimulation of the uterus, which can lead to hypertonia and tetanic contractions of the uterus, which in turn can lead to rupture of the uterus, postpartum hemorrhage, various changes in cardiac fetal activity, hypoxia and fetal death;
contraction of the fetus, fetal asphyxia, fetal bradycardia, utero-placental hypoperfusion, hypercapnia, birth injuries of the fetus, water intoxication, convulsions.
Treatment: Immediately stop the administration of oxytocin, reduce fluid administration, force diuresis, introduce symptomatic drugs and hypertensive saline solutions (to normalize the electrolyte balance), barbiturates (with caution).
Careful observation is necessary for the patient.

With caution use oxytocin in combination with sympathomimetics (potentiates pressor action of sympathomimetics).

In combination with MAO inhibitors, the risk of increasing blood pressure increases.
Halothane and cyclopropane increase the risk of developing arterial hypotension.

The drug is released by prescription.


List B. The drug should be stored at a temperature not higher than 25 В° C.
Do not freeze! Keep out of the reach of children!
Shelf life - 4 years.
Do not use after the expiration date.
Alphabetical index of medicines:
A  B  V  G  D  E  J
Z  I  Y  K  L  M  N
O  P  R  S  T  U  F
H  C  CH  SH  E  U  Y

Privacy policy:
Copyright 2009 - 2017. Universal reference book of medicines. All rights reserved.
When using site materials, an active hyperlink is required!