Universal reference book for medicines
Product name: OXYCORT

Active substance: hydrocortisone, oxytetracycline

Type: The drug with antibacterial and anti-inflammatory action for external use

Composition, form of production and packaging
Ointment for external use is
uniform, yellow in color.

1 g

hydrocortisone acetate 10 mg

Oxytetracycline (in the form of hydrochloride) 30 mg

Excipients: white petrolatum - up to 1 g.

10 g - aluminum tubes (1) - packs of cardboard.


Description of the drug approved by the manufacturer for the printed edition of 2013.


Combination drug with antibacterial and anti-inflammatory action for external use.

Oxytetracycline is an antibiotic of the tetracycline group.
It has a bacteriostatic effect by inhibiting translation during protein synthesis in microbial cells.
It is active against gram-positive bacteria: Staphylococcus spp.
(including those producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Clostridium spp., Bacillus anthracis, Listeria monocytogenes; Gram-negative bacteria: Neisseria gonorrhoeae, Bordetella pertussis, Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp .; as well as in relation to: Rickettsia spp., Chlamydia spp., Mycoplasma spp., Actinomyces spp., Mycobacterium spp., Spirochaetaceae.
Hydrocortisone - synthetic GCS, has anti-inflammatory, antipruritic, anti-exsudative action.
It inhibits the release of cytokines (interleukins and interferon) from lymphocytes and macrophages, inhibits the release of eosinophils mediators of inflammation, disrupts the metabolism of arachidonic acid and the synthesis of prostaglandins. Stimulating glucocorticoid receptors induces the formation of lipocortin. Reduces inflammatory cell infiltrates, reduces the migration of leukocytes, incl. lymphocytes into the area of ​​inflammation. When applied externally at recommended doses, it does not cause systemic side effects.
As a result of the combined effect of hydrocortisone and oxytetracycline, the drug suppresses the development of inflammatory-allergic skin reactions complicated by bacterial infection.


After applying the ointment to the skin, the active components of the drug accumulate in the epidermis (mainly in the granular layer).

Oxytetracycline, when used externally, is practically not absorbed and does not have a systemic effect, and a small amount that has got into the systemic bloodstream as a result of absorption is biotransformed in the liver and excreted by the kidneys.

Hydrocortisone after application accumulates in the epidermis (mainly in the granular layer).
Metabolized directly in the epidermis, and later - in the liver. It is excreted by the kidneys and through the intestines.

Diseases of the skin complicated by a secondary bacterial infection caused by microorganisms sensitive to oxytetracycline:

- allergic dermatitis;

contact dermatitis;

- professional dermatitis;

- seborrheic dermatitis;

- sunny dermatitis;

- atopic dermatitis;

- pruritis;

- eczema;

- multiforme exudative erythema;

- psoriasis;

- burns of I-II degree;

- frostbite.


Assign externally.
Ointment is applied a thin layer on the affected skin 2-3 times / day. The use of gauze occlusive dressing is possible. The course of treatment is 1-2 weeks.
When applied to the face, avoid applying ointment to the periorbital area.

In children older than 2 years, the drug should be applied to limited areas of the skin and apply a short course (for 5-7 days).


Dermatological reactions: possible - itching, rash and skin irritation;
with prolonged use possible - acne, telangiectasia, striae, skin atrophy.

- viral skin diseases;

- tuberculosis;

- syphilis;

- dermatomycosis;

- neoplasm and precancerous skin diseases;

- rosacea and perioral dermatitis;

- skin reactions after vaccination;

- Pregnancy;

- the period of lactation (breastfeeding);

- Children under 2 years;

- Hypersensitivity to the components of the drug.


It is not recommended to prescribe Oxycorta during pregnancy and lactation, especially long and on large areas of the skin.


Contraindicated in children under 2 years.
In children older than 2 years The drug should be applied to limited areas of the skin and apply a short course (for 5-7 days).

Do not exceed the recommended course of treatment and apply the drug to large areas of the skin.

Avoid contact with ointment in the eyes.

If it is necessary to apply the drug on the skin of the face and in the skin folds, the course of treatment should be short (within 5-7 days).

Impact on the ability to drive vehicles and manage mechanisms

The drug does not limit psychophysical activity, ability to drive vehicles and service moving mechanisms.


Overdose is very rare.

Symptoms: with long-term use of preparations containing GCS, incl.
Oxycorta, on the vast surface of the skin can suppress the function of the adrenal cortex with the development of secondary adrenal insufficiency and symptoms of hypercorticism, including Itenko-Cushing syndrome. Overdose of oxytetracycline may lead to an increase in insensitive microflora
Treatment: symptomatic therapy.
Acute symptoms of hypercorticoidism are usually reversible. If necessary, correct the electrolyte balance.

With external use of the drug, interactions with other drugs have not been identified.


The drug is released by prescription.


The drug should be stored out of the reach of children at a temperature of no higher than 25 В° C.
Shelf life - 2 years.
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