Universal reference book for medicines
Product name: LOFOX ® (LOFOX)

Active ingredient: lomefloxacin

Type: Antibacterial drug of the group of fluoroquinolones for topical application in ophthalmology

Manufacturer: SYNTHESIS (Russia) manufactured SYNTHESIS (Russia) trademark owner BIOKOM TECHNOLOGY (Republic of Belarus)
Composition, form of production and packaging
Eye drops 0.3%
in the form of a clear or slightly opalescent liquid, colorless or light yellow in color.

1 ml

Lomefloxacin (in the form of hydrochloride) 3 mg

Auxiliary substances: glycerol (glycerin distilled) - 25 mg, disodium edetate - 0.1 mg, benzalkonium chloride - 0.1 mg, sodium hydroxide r-p 1M - to pH 4.8-5.0, water d / u - up to 1 ml.

5 ml - a bottle-droppers polymer (1) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2013.

PHARMACHOLOGIC EFFECT

Antimicrobial bactericidal preparation of a broad spectrum of action from the group of fluoroquinolones (a subgroup of difluoroquinolones).
Affects the bacterial enzyme DNA-gyrase, which provides supercoiling, forms a complex with its tetramer (subunit of gyrase A2B2) and disrupts transcription and replication of DNA, leads to the death of the microbial cell. It is bactericidal.
β-lactamases produced by pathogens do not affect lomefloxacin activity.

The drug is highly active against gram-negative aerobic microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter diversus, Klebsiella pneumoniae, Enterobacter cloacae, Proteus vulgaris, Salmonella spp., Shigella spp., Moraxella catarrhalis, Morganella morganii, Haemophilus influenzae, Haemophilus parainfluenzae, Legionella pneumophila.

The drug is moderately sensitive: Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Serratia liquefaciens, Serratia marcescens, Mycobacterium tuberculosis, Chlamydia trachomatis, Hafnia alvei, Citrobacter freundii, Aeromonas hydrophila, Proteus mirabilis, Proteus stuartii, Providencia rettgeri, Providencia alcalifaciens, Klebsiella oxytoca, Klebsiella ozaenae, Enterobacter aerogenes, Enterobacter agglomerans.

The drug is resistant to: Streptococcus spp., Pseudomonas cepacia, Ureaplasma urealyticum, Treponema pallidum, Mycoplasma hominis and anaerobic
bacteria.
PHARMACOKINETICS

After instillation, 1 drop every 1 day for 2 days and 5 drops for 3 days T max 90 min, C max 1 μg / ml for 2.5 hours. Therapeutic concentration in the cornea, sclera, eyelid, conjunctiva and intraocular fluid It is achieved after 5 instillations in 1 drop at intervals of 5 minutes.
The content in the lacrimal fluid after 1-2 instillations is: 40-200 μg / ml - after 2 hours, 7-27 μg / ml - after 6 hours or more, 3 μg / ml - after 24 hours.
INDICATIONS

- bacterial infections of the anterior part of the eye (conjunctivitis, blepharitis, blepharoconjunctivitis, including chlamydial etiology).

DOSING MODE

Adults appoint 1 drop 2-3 times / day in the lower conjunctival sac for 7-9 days.
At the beginning of treatment, more frequent use is necessary: ​​5 drops for 20 minutes (1 drop at intervals of 5 minutes) or 1 drop / h for 6-10 hours.
For the treatment of chlamydial conjunctivitis 1 drop of the drug is instilled in the conjunctival sac of the affected eye 2-4 times / day for 1-2 months.

SIDE EFFECT

Local reactions: burning sensation;
with prolonged use - the development of secondary fungal infection.
CONTRAINDICATIONS

- Pregnancy;

- the period of lactation (breastfeeding);

- children and adolescence under 18;

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

Application in pregnancy is not recommended.
When appointing during lactation, breastfeeding should be discontinued.
APPLICATION FOR CHILDREN

The drug is contraindicated in childhood and adolescence.

SPECIAL INSTRUCTIONS

During the period of treatment, contact lenses should be avoided.

Impact on the ability to drive vehicles and manage mechanisms

During the period of treatment, care should be taken when driving vehicles and engaging in potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions.

OVERDOSE

There is no information about an overdose.

DRUG INTERACTION

There is no data on drug interaction.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of reach of children, protected from light at a temperature of 15 ° to 25 ° C.
Do not freeze! Shelf life - 2 years.
After opening the vial, the shelf life is 1 month.

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