Universal reference book for medicines

Active ingredient: lomefloxacin

Type: Antibacterial drug of the group of fluoroquinolones

Manufacturer: FARMASINTEZ (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

Antimicrobial agent of the group of fluoroquinolones.
Has a bactericidal effect. Inhibits the activity of DNA-gyrase, an enzyme involved in the transcription and replication of bacterial DNA.
Highly active against aerobic gram-negative bacteria: Escherichia coli, Salmonella spp., Citrobacter diversus, Enterobacter cloacae, Haemophilus influenzae, Klebsiella pneumoniae, Proteus vulgaris, Morganella morganii, Legionella pneumophila, Neisseria gonorrhoeae, Neisseria meningitidis, Moraxella catarrhalis.

Lmefloxacin is moderately sensitive to Proteus mirabilis, Proteus stuartii, Providencia rettgeri, Pseudomonas aeruginosa, Serratia liquefaciens, Serratia agglomerans, Haemophilus parainfluenzae, Providencia alcalifaciens, Aeromonas hydrophila, Hafnia alvei, Mycobacterium tuberculosis, Chlamydia trachomatis, and some gram positive aerobic bacteria (Staphylococcus aureus, Staphylococcus epidermidis).

Lomefloxacin is resistant to Streptococcus spp., Pseudomonas cepacia, Ureaplasma urealyticum, Mycoplasma hominis and anaerobic bacteria.

Lomefloxacin has anti-tuberculosis activity, acting both on the extracellular and intracellularly located Mycobacterium tuberculosis.

After ingestion, lomefloxacin is almost completely absorbed from the digestive tract, the absorption is 95-98%.
Binding to plasma proteins - 10%.
Widely distributed in the body.
Concentrations in tissues and body fluids are usually 2-7 times higher than in plasma, especially in the tissues of the prostate and urine.
T 1/2 lomefloxacin is 7-9 hours. About 70-80% is excreted unchanged in the urine for 24 hours.

In patients with impaired renal function, T 1/2 significantly increased.

Infectious-inflammatory diseases caused by micro-organisms sensitive to lomfloxacin, incl.
urinary tract infection (cystitis, pyelonephritis), prostatitis; infections of the lower respiratory tract; acute and chronic purulent infections of soft tissues, infected wounds, osteomyelitis; Cholera (severe form); tuberculosis (as part of combination therapy); acute and chronic gonorrhea; acute and recurrent chlamydia.
Prevention of infectious complications of the urinary tract before and after transurethral surgery.

For topical application in ophthalmology: bacterial infections of the anterior part of the eye (including conjunctivitis, blepharitis, blepharoconjunctivitis).

When administered orally, the daily dose is 400-800 mg, the frequency of treatment and the duration of treatment are set individually.

Locally in ophthalmology apply 2-3 times / day for 7-10 days.
At the beginning of treatment, more frequent use is recommended.
From the digestive system: nausea, vomiting, diarrhea.

From the side of the central nervous system: headache, anxiety, sleep disturbances.

Dermatological reactions: in some cases - photosensitivity, skin rash.

Effects caused by chemotherapeutic action: with prolonged use, candidiasis is possible.

Local reactions: rarely - a burning sensation that occurs immediately after instillation.

Pregnancy, lactation (breastfeeding), children and adolescents under 15, hypersensitivity to quinolone derivatives.

Lomefloxacin is contraindicated in pregnancy and lactation (breast-feeding).

When renal dysfunction is required, correction of the dosing regimen is required depending on the CK values.

Contraindicated in children and adolescents under 15 years.

With caution should be used for severe cerebral atherosclerosis, epilepsy and other diseases of the central nervous system.

When renal dysfunction is required, correction of the dosing regimen is required depending on the CK values.

During the treatment period, prolonged exposure to sunlight and the use of artificial ultraviolet light should be avoided.

Do not use topically with antibiotics for use in ophthalmology, acting bacteriostatically.

Vitamins with mineral supplements should be used 2 hours before or 2 hours after the application of Lomefloxacin.

It should be borne in mind that with the use of fluoroquinolones, peripheral neuropathy is possible;
undesirable influence on tendons (including ruptures) both during and after therapy; cumulation of caffeine, leading to stimulation of the central nervous system; pseudomembranous colitis; prolongation of the QT interval c (risk of ventricular arrhythmia, including pirouette).
With simultaneous use with antacids and sucralfate, chelate complexes are formed, which reduces the bioavailability of lomefloxacin (antacids and sucralfate should not be taken within 4 hours before and 2 hours after taking lomefloxacin).

With simultaneous use with rifampicin (in patients with tuberculosis) antagonism of the action is observed.

With concomitant use, lomefloxacin practically does not inhibit theophylline metabolism.

With the simultaneous use of lomefloxacin and caffeine in high doses, it is possible to increase the half-life of the latter.

Drugs that block tubular secretion, slow the excretion of lomefloxacin.

With the simultaneous use of lomefloxacin increases the activity of oral anticoagulants and increases the toxicity of NSAIDs.

With the simultaneous use of fluoroquinolones with NSAIDs, it is possible to develop seizures.

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