Universal reference book for medicines
Product name: LOXON-400 (LOCSONE-400)

Active substance: norfloxacin

Type: Antibacterial drug of the group of fluoroquinolones

Manufacturer: MICRO LABS (India)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Antimicrobial synthetic agent of the group of fluoroquinolones of wide spectrum of action.
Has a bactericidal effect. Suppressing the DNA-gyrase, violates the process of supercoiling of DNA.
Highly active against most Gram-negative bacteria: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Morganella morganii, Klebsiella spp.
(including Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis.
It is active against some Gram-positive bacteria (including Staphylococcus aureus).

To norfloxacin resistant anaerobic bacteria are resistant, low-sensitivity Enterococcus spp.
and Acinetobacter spp.
Resistant to the action of? -lactamases.

PHARMACOKINETICS
When ingested absorbed about 30-40%, eating reduces the absorption rate.
Binding to plasma proteins is 14%. Norfloxacin is well distributed in the tissues of the urogenital system. Penetrates through the placental barrier. About 30% is excreted unchanged in urine.
INDICATIONS
Infectious-inflammatory diseases caused by microorganisms sensitive to norfloxacin.

For oral administration: diseases of the urinary tract, prostate, GIT, gonorrhea, prevention of recurrence of urinary tract infections, bacterial infections in patients with granulocytopenia, traveler's diarrhea.

For topical application: conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute inflammation of the meibomian glands and dacryocystitis, prevention of eye infections after removal of the foreign body from the cornea or conjunctiva, after chemical damage, before and after surgical interventions on the eyes;
otitis externa, acute otitis media, chronic otitis media, prevention of infectious complications during surgical interventions on the hearing organ.
DOSING MODE
Individual.
A single dose for ingestion is 400-800 mg, the frequency of application - 1-2 times / day. The duration of treatment is determined individually.
In ophthalmology and ENT-practice apply topically.

SIDE EFFECT
From the digestive system: nausea, heartburn, anorexia, diarrhea, abdominal pain.

From the side of the central nervous system: headache, dizziness, a sense of fatigue, sleep disorders, irritability, anxiety.

Allergic reactions: skin rash, itching, angioedema.

Co of the urinary tract: interstitial nephritis.

CONTRAINDICATIONS
Pregnancy, lactation (breastfeeding), children and adolescence (up to 15 years), deficiency of glucose-6-phosphate dehydrogenase, hypersensitivity to norfloxacin and other drugs of the quinolone series.

PREGNANCY AND LACTATION
Norfloxacin is contraindicated in pregnancy and lactation (breastfeeding), because in experimental studies it is established that it causes arthropathy.

APPLICATION FOR FUNCTIONS OF THE LIVER
It should be used with caution in patients with severe renal dysfunction.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
It should be used with caution in patients with severe impairment of liver function.

APPLICATION FOR CHILDREN
Contraindicated in childhood and adolescence (up to 15 years).

SPECIAL INSTRUCTIONS
It should be used with caution in patients with epilepsy, convulsive syndrome of another etiology, with severe impairment of kidney and liver function.
During treatment, patients should receive a sufficient amount of fluid (under the control of diuresis).
Norfloxacin should be taken at least 2 hours before or 2 hours after ingestion of antacid agents or preparations containing iron, zinc, magnesium, calcium or sucralfate.

DRUG INTERACTION
With the simultaneous use of norfloxacin with warfarin, the anticoagulant effect of the latter is enhanced.

With the simultaneous use of norfloxacin with cyclosporine, there is an increase in the concentration of the latter in the blood plasma.

With the simultaneous administration of norfloxacin and antacid agents or preparations containing iron, zinc, magnesium, calcium or sucralfate, the absorption of norfloxacin is reduced due to the formation of complexons with metal ions (the interval between their intake should be at least 4 hours).

With the simultaneous administration of norfloxacin reduces the clearance of theophylline by 25%, so with simultaneous use should reduce the dose of theophylline.

Simultaneous administration of norfloxacin with drugs that have the potential to reduce blood pressure can cause a sharp decrease in blood pressure.
In this regard, in such cases, as well as with the simultaneous introduction of barbiturates, anesthetics, it is necessary to monitor heart rate, blood pressure, ECG parameters.Simultaneous use with drugs that reduce the epileptic threshold may lead to the development of epileptiform seizures.
Reduces the effect of nitrofurans.

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