Universal reference book for medicines

Active substance: polihexanide

Type: Antiseptic for external use

Manufacturer: B.BRAUN MEDICAL (Germany) manufactured by SOLUPHARM (Germany)
Composition, form of production and packaging
Concentrate for the preparation of a solution for external use
1 ml

polyhexanide 200 mg

pH 5.0-7.0

Excipients: water d / u, macrogol 400 (PEG) 10 mg.

5 ml - bottles (5) - packs cardboard.


Description of the drug approved by the manufacturer for the printed edition of 2005.


Antiseptic preparation.
Polyhexanide has a broad spectrum of antimicrobial activity. It is active against gram-positive and gram-negative bacteria (including Pseudomonas aeruginosa), fungi.
Polyethylene glycol (PEG) reduces the surface tension, which enhances the action of polyhexanide.

In the presence of protein (0.2% albumin), the effect of the drug is only slightly weakened, and a good fungicidal and bactericidal effect is detected during the quantitative tests.

The drug does not contain substances that have an irritant effect: halogen- and mercury-containing antiseptics, iodine, heavy metals, polyvinylpyrrolidone and aldehydes.

Polyhexanide is chemically stable, non-volatile, odorless, soluble in water, ethanol, glycerol, propylene glycol and other solvents.

Polyhexanide has a weak toxicity, and the content of polyethylene glycol in Lavasept concentrate is small in order to increase the toxicity of polyhexanide.


When external application was not observed systemic absorption (the concentration of active substance in the blood and urine was below 10 μg / ml - the possible level of detection).
Nor was it found in cases of washing or constant irrigation of extensive surgical wounds during operations that lasted 2 hours or more without the use of a tourniquet.
Systemic absorption was not determined when using dressings with a preparation for wound dressing for several weeks (in 1 case the maximum period was 58 weeks).


- antiseptic treatment in the surgical treatment of infected wounds and superficial soft tissue damage;

- washing of cavities through drainage tubes using active drainage;

- irrigation of the operating field during surgical intervention in reconstructive operations, immediately before bone and soft tissue transplantation;

- irrigation of the operating field during operations with the existing threat of infection;

- Treatment of infected wounds during the operation of hip replacement (according to Schneider);

antiseptic protection of open wounds;

- burn surface treatment;

-Antiseptic treatment for maxillofacial operations;

-processing of surgical instruments, dressing material and items of patient care.


Lavasept concentrate is used only externally.
Before use, Lavasept concentrate should be diluted to a concentration of 0.1% or 0.2%.
To wash and drain the wounds , use a 0.1% solution of Lavasept concentrate.

In case of infection of wounds with gram-negative flora , 0.2% solution of the drug is used.

Rules for the preparation of solution

To prepare 0.1% or 0.2% Lavasept solution to 1000 ml Ringer's solution, add 1 ml or 2 ml of Lavasept concentrate, respectively.
When mixed with other solutions, cloudiness and precipitation should be avoided. The polyhexanide precipitated at low temperatures can be dissolved by heating the solution to 60 ° C.

Allergic reactions: skin rash, hives.


-operations on uninfected joints;

-operations on the brain and spinal cord (neurosurgical operations);

on the middle and inner ear;

-operations on the eyes (ophthalmic operations);

- intraperitoneal lavage;

-increased sensitivity to the components of the drug.


Currently, there is insufficient data on the use of Lavasept concentrate during pregnancy and lactation.
It is not recommended to use the drug in the first trimester of pregnancy. In later terms of pregnancy and lactation, the application is only possible if the intended benefit to the mother exceeds the possible risk to the fetus or the baby.

In pediatric practice 0.1% Lavasept solution of concentrate is used.
Due to the lack of experience with the use of Lavasept concentrate in children under 3 years of age, use of the drug in patients of this age group is possible only after a thorough assessment of the risk-benefit ratio.

When allergic reactions occur, the use of Lavasept concentrate should be immediately stopped and antiallergic therapy (antihistamines) should be prescribed.

When applying Lavasept concentrate, you should avoid delaying it in tissues.

In experimental studies on animals, it was shown that Lavasept concentrate inhibits the growth of cartilage tissue of embryos.
With prolonged use, Lavasept can damage intact cartilage. Therefore, Lavasept concentrate should not be used to flush uninfected joints. If you accidentally get the drug on an intact cartilaginous tissue during an operation on an uninfected joint, the entire joint should be rinsed with Ringer's solution or physiological solution.
When using Lavasept concentrate on inflamed and infected joints, with significant lesions, in cases when arthrodesis or total replacement of the joint is planned, Lavasept concentrate can create the optimal level of disinfection, which provides a favorable outcome of the operation.

Use in Pediatrics

In pediatric practice 0.1% Lavasept solution of concentrate is used.
Due to the lack of experience with the use of Lavasept concentrate in children under 3 years of age, use of the drug in patients of this age group is possible only after a thorough assessment of the risk-benefit ratio.

Cases of overdose are not described.


Currently, cases of drug interaction are not known.


The drug should be stored at a temperature of 8 ° to 25 ° C.
Do not freeze. Shelf life - 3 years.
The prepared solution should be used within 48 hours.

Conditions of leave from pharmacies

The drug is released by prescription.

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