Composition, form of production and packaging
The solution for intravenous and / or injection is colorless, transparent.
xanthinal nicotinate 150 mg
Auxiliary substances: water d / and (up to 1 ml).
2 ml - ampoules (10) - cardboard boxes.
INSTRUCTION FOR THE SPECIALIST.
The product description was approved by the manufacturer for the 2009 print edition.
The drug combines the properties of theophylline and nicotinic acid: causes the expansion of peripheral vessels, improves collateral circulation, improves oxygenation and nutrition of tissues, enhances oxidative phosphorylation and synthesis of ATP. Xanthinal nicotinate improves cerebral circulation and reduces the phenomenon of cerebral hypoxia. The drug also activates the processes of fibrinolysis, reduces the aggregation of platelets.
- endarteritis of the vessels of the lower extremities;
- diabetic angiopathy;
- Acute thrombophlebitis of superficial and deep veins;
- builderboflebichesky syndrome;
- trophic ulcers of the lower extremities:
- pressure sores;
- Meniere's syndrome;
- dermatoses associated with a disorder of vascular trophism;
- impaired cerebral circulation.
With acute violations of blood supply to tissues, the drug is injected in / m of 0.3 g (2 ml of 15% solution) 1-3 times / day. Depending on the nature of the disease, the dose can be gradually increased to 0.6-0.9 g (4-6 ml of 15% solution) 2-3 times / day. Duration of treatment is 2-3 weeks.
With acute violations of the peripheral and cerebral circulation of Xanthinal, nicotinate is injected iv by drop at a speed of 40-50 drops / min. To do this, 1.5 g (10 ml of 15% solution) of the drug is diluted in 200-500 ml of 5% glucose solution or in 200 ml of isotonic sodium chloride solution, the infusion mixture is injected for 1.5-4 hours. Infusion can be repeated up to 4 times / day; the duration of treatment is 5-10 days.
Xanthinal nicotinate can cause dizziness, lowering blood pressure, general weakness, a feeling of heat, tingling and redness of the upper body, especially the neck and head, nausea, anorexia, diarrhea. These symptoms usually disappear after 10-20 minutes, do not require special treatment and discontinuation of therapy with this drug. If unwanted effects not described in this manual occur and if the above side effects are increased with this medication, tell your doctor immediately.
With long-term administration of high doses, the drug causes a change in glucose tolerance, an increase in the activity of hepatic transaminases, alkaline phosphatase, hyperuricemia.
- Acute heart failure, incl. acute myocardial infarction;
- chronic heart failure IIB-III degree;
- mitral stenosis;
- arterial hypotension;
- Acute bleeding;
- Stomach ulcer and duodenal ulcer in the stage of exacerbation;
acute renal failure;
- pregnancy I trimester;
- increased individual sensitivity to the components of the drug.
PREGNANCY AND LACTATION
Contraindicated in the first trimester. In the II and III trimesters of pregnancy and during lactation, the use of the drug is permissible only in the presence of absolute indications and careful observation of the doctor.
APPLICATION FOR FUNCTIONS OF THE LIVER
Contraindicated in acute renal failure.
APPLICATION FOR CHILDREN
Xanthinal nicotinate causes nicotine-like syndrome, accompanied by hyperesthesia of the mucous membrane of the nose and mouth (sharpens the sensitivity of the olfactory and taste buds) in this regard, the smell and taste of alcoholic beverages taken during therapy is perceived to be more abrupt and perverted.
Avoid contact with eyes or mucous membranes.
Impact on the ability to drive vehicles and manage mechanisms
Large doses of the drug may cause dizziness, weakness and arterial hypotension, therefore, one should refrain from driving a vehicle and working with mechanisms.
The drug is low toxicity.
Symptoms: An early overdose of xanthinal nicotinate is accompanied by arterial hypotension, general weakness, dizziness, tachycardia, abdominal pain and vomiting.
Treatment: when symptoms of an overdose are prescribed symptomatic therapy.
To avoid a sharp drop in blood pressure, the drug should not be used simultaneously with antihypertensive drugs. It can not be combined with therapy with MAO inhibitors, strophanthin.
TERMS OF RELEASE FROM PHARMACY
The drug is released by prescription.
TERMS AND CONDITIONS OF STORAGE
List B. Store in a place protected from light and inaccessible to children at a temperature of no higher than 25 В° C. Shelf life - 3 years.