Universal reference book for medicines

Active substance: cocarboxylase

Type: A drug that improves the metabolism and energy supply of tissues

Producer: NGO MIKROGEN (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

Coenzyme formed in the body from thiamine.
Has a metabolic action, activates tissue metabolism. In the body, phosphorylated to form mono-, di- and triphosphate esters; kokarboksilaza is a part of the enzymes that catalyze the carboxylation and decarboxylation of keto acids, pyruvic acid, promotes the formation of acetyl-coenzyme A, which determines its participation in carbohydrate metabolism. Participation in the pentose cycle indirectly promotes the synthesis of nucleic acids, proteins and lipids.
Improves the absorption of glucose, trophic nervous tissue, contributes to the normalization of the functions of the cardiovascular system.

Deficiency of cocarboxylase causes an increase in the level of pyruvic and lactic acids in the blood, which leads to acidosis and an acidotic coma.

In the combination therapy: metabolic acidosis, acidosis in hyperglycemic coma, acidosis with respiratory and pulmonary heart failure;
chronic heart failure, IHD, unstable angina, myocardial infarction, postinfarction cardiosclerosis; hepatic and / or renal failure, acute and chronic alcoholism, poisoning, intoxication with cardiac glycosides and barbiturates, infectious diseases (diphtheria, scarlet fever, typhoid fever, paratyphoid), neuralgia, multiple sclerosis, peripheral neuritis.
In children during the newborn period: perinatal hypoxic encephalopathy, respiratory failure, pneumonia, sepsis, hypoxia, acidosis.

Adults are injected in / m or IV.
The dose is 50-200 mg / day. In diabetes (acidosis, coma) daily dose can be 0.1-1 g. Frequency and duration of use depends on the indications.
Children - in / m, in / in (drip or jet), the newborn - sublingual.
Children up to 3 months - 25 mg / day, from 4 months to 7 years - 25-50 mg / day, from 8 to 18 years - 50-100 mg / day. Duration of treatment - from 3-7 to 15 days.
Possible: allergic reactions (hives, itching).

With the / m introduction: possible hyperemia, itching, swelling at the injection site.

Hypersensitivity to cocarboxylase.

The application is possible according to the dosing regimen.

Strengthens cardiotonic action of cardiac glycosides and improves their tolerability.

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