Composition, form of production and packaging
Iodomarin В® 100
? Tablets are white or almost white, round, flat-cylindrical, with a facet and a risk on one side.
1 tab.
potassium iodide 131 Ојg,
which corresponds to an iodine content of 100 Ојg
Excipients: lactose monohydrate - 75.119 mg, magnesium carbonate basic - 28.25 mg, gelatin - 4 mg, sodium carboxymethyl starch (type A) - 4.75 mg, silicon colloidal dioxide - 1.75 mg, magnesium stearate - 1 mg.
50 pcs. - bottles (1) - packs of cardboard.
100 pieces. - bottles (1) - packs of cardboard.
Iodomarin В® 200
? Tablets are white or almost white, round, flat-cylindrical, with a facet and a risk on one side.
1 tab.
potassium iodide 262 Ојg,
which corresponds to the content of iodine 200 mg
Excipients: lactose monohydrate 150.238 mg, magnesium carbonate basic 56.5 mg, gelatin 8 mg, sodium carboxymethyl starch (type A) 9.5 mg, silicon colloidal dioxide 3.5 mg, magnesium stearate 2 mg.
25 pcs. - blisters (2) - packs of cardboard.
25 pcs. - blisters (4) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2014.
PHARMACHOLOGIC EFFECT
Iodine preparation for the treatment and prevention of thyroid diseases. Iodine is a vital microelement necessary for the normal functioning of the thyroid gland.Thyroid hormones perform a lot of vital functions, including. regulate the exchange of proteins, fats, carbohydrates and energy in the body, the activity of the brain, nervous and cardiovascular systems, sex and breast, and the growth and development of the child.
The use of the drug Jodomarin В® replenishes iodine deficiency in the body, preventing the development of iodine deficiency diseases, contributing to the normalization of thyroid function, which is especially important for children and adolescents, as well as during pregnancy and lactation.
PHARMACOKINETICS
Data on the pharmacokinetics of the preparation Jodomarin В® are not provided.
INDICATIONS
- prevention of endemic goiter (especially in children, adolescents, in women during pregnancy and during breastfeeding);
- prevention of recurrence of goiter after surgical removal or after the end of drug treatment with drugs of thyroid hormones;
- treatment of diffuse euthyroid goiter caused by iodine deficiency in children, adolescents and adults under the age of 40 years.
DOSING MODE
Prevention of endemic goiter
Newborns and children under the age of 12 years
1 / 2-1 tab. preparation Jodomarin В® 100 or 1/2 tab. iodomarin В® 200 per day (corresponding to 50-100 Ојg of iodine).
Children are over 12 years old and adults
1-2 tablets. preparation Jodomarin В® 100 or 1 / 2-1 tab. of the drug Iodomarin В® 200 per day (corresponding to 100-200 Ојg of iodine).
During pregnancy and lactation
2 tab. preparation Iodomarin В® 100 or 1 tab. of the drug Jodomarin В® 200 per day (corresponding to 200 Ојg of iodine).
Prophylaxis of goitre recurrence
1-2 tablets. preparation Jodomarin В® 100 or 1 / 2-1 tab. of the drug Iodomarin В® 200 per day (corresponding to 100-200 Ојg of iodine).
Treatment of euthyroid goiter
Newborns and children aged 1 to 18 years
1-2 tablets. preparation Jodomarin В® 100 or 1 / 2-1 tab. of the drug Iodomarin В® 200 per day (corresponding to 100-200 Ојg of iodine).
Adults under the age of 40
3-5 tab. preparation Jodomarin В® 100 per day or 1 1/2 -2 1/2 tab. drug Jodomarin В® 200 per day (which corresponds to 300-500 Ојg of iodine).
The drug is taken after a meal, squeezed with enough liquid. When used in children, it is recommended to pre-dissolve the drug in milk or juice.
Prophylactic reception is carried out for several years, in the presence of indications - for life.
To treat goiter in newborns, on average, 2-4 weeks is enough; children, adolescents and adults usually need 6-12 months, a long reception is possible.
The duration of treatment is established by the attending physician.
SIDE EFFECT
With the preventive use of the drug Jodomarin В® in patients of any age, side effects are usually not observed.
On the part of the endocrine system: when using the drug at a dose of more than 150 micrograms of iodine / day, latent hyperthyroidism can go into a manifest form;when the drug is used in a dose exceeding 300 mcg iodine / day, iodine-induced thyrotoxicosis may develop (especially in elderly patients with goitre for a long time in the presence of nodular goiter or diffuse toxic goiter).
Allergic reactions: rarely - iodism, manifested by a metallic taste in the mouth, swelling and inflammation of the mucous membranes (iodine rhinitis, conjunctivitis, bronchitis), iodine fever, iodine acne; in some cases - Quincke's edema, exfoliative dermatitis.
CONTRAINDICATIONS
- hyperthyroidism;
- toxic adenoma of the thyroid gland, nodular goiter when applied at doses of more than 300 Ојg / day (with the exception of the period of pre-operative iodine therapy to block the function of the thyroid gland);
- herpetiform (senile) dermatitis of DГјhring;
- hypersensitivity to iodine.
The drug should not be used for hypothyroidism, except when the development of the latter is caused by a pronounced iodine deficiency.
It should avoid the appointment of the drug in therapy with radioactive iodine, the presence or suspected of thyroid cancer.
PREGNANCY AND LACTATION
During pregnancy and lactation, the need for iodine increases, so it is especially important to use the drug Jodomarin В® in sufficient doses (200 mcg / day) to ensure adequate intake of iodine in the body.
The use of the drug Jodomarin В® during pregnancy and lactation (breastfeeding) is possible only in recommended doses, t. The active substance penetrates the placenta and is excreted in breast milk.
APPLICATION FOR CHILDREN
Possible use in children according to indications.
SPECIAL INSTRUCTIONS
Impact on the ability to drive vehicles and manage mechanisms
Iodomarin В® does not affect the ability to drive vehicles and other potentially hazardous activities.
OVERDOSE
Symptoms: staining the mucous membranes in brown, reflex vomiting (if the food contains starch containing components, vomit becomes blue), abdominal pain and diarrhea (possibly, melena). In severe cases, the development of dehydration and shock is possible. In rare cases stenosis of the esophagus, the phenomenon of "iodism" was observed .
Treatment: for acute intoxication - drug withdrawal, gastric lavage with starch solution, protein or 5% sodium thiosulfate solution until all traces of iodine are removed; with chronic intoxication - withdrawal of the drug. Symptomatic therapy of disturbance of water balance, electrolyte balance, anti-shock therapy.
In the treatment of iodine-induced hypothyroidism - the abolition of the drug, the normalization of metabolism with the help of thyroid hormones.
In the treatment of iodine-induced thyrotoxicosis - with mild forms of treatment is not required, with severe forms, the use of thyrostatic therapy is required (the effect of which is always delayed). In severe cases (thyrotoxic crisis), intensive therapy, plasmapheresis or thyroidectomy is necessary.
DRUG INTERACTION
Iodine deficiency increases, and excess iodine lowers the effectiveness of thyroid therapy with hyperthyroidism (before or during treatment of hyperthyroidism it is recommended, whenever possible, to avoid any use of iodine). On the other hand, thyreostatics inhibit the transition of iodine to an organic compound in the thyroid and, thus, can cause the formation of goiter.
Simultaneous treatment with high doses of iodine and preparations of lithium salts can promote the appearance of goiter and hypothyroidism.
High doses of the drug in combination with potassium-sparing diuretics can lead to hyperkalemia.
TERMS OF RELEASE FROM PHARMACY
The drug is approved for use as a means of OTC.
TERMS AND CONDITIONS OF STORAGE
The drug should be stored out of reach of children, dry, protected from light at a temperature of no higher than 25 В° C. Shelf life - 3 years.
