Universal reference book for medicines

Active substance: nonappropriate

Type: Immunological preparation.
Composition, form of production and packaging
A set of ampoules (10 pcs.) - packs of cardboard.

Solution for the / m introduction 1 amp.

Immunoglobulin Antisibiria Equivalent horse 10 ml

10 ml - ampoules - 5 pcs.

Solution for the / m introduction 1 amp.

immunoglobulin, antisibiria, equine, diluted 1 ml

1 ml - ampoules - 5 pcs.


Description of the drug approved by the manufacturer for the printed edition of 2014.


Immunoglobulin protivosibireyzvenny horse contains specific antibodies, has antibacterial action against the causative agent of anthrax and antitoxic action against anthrax toxin.


Emergency prophylaxis and treatment of anthrax in humans.

For the purpose of emergency prevention, the drug is prescribed in the following cases:

- direct contact with the material containing an agent of anthrax;

- when caring for anthrax patients with animals;

- at slaughter and cutting of carcasses of sick animals;

- when cooking and eating meat of sick animals.

Emergency preventive administration of the drug is made to persons not vaccinated against anthrax.

With a therapeutic purpose, the drug is prescribed for moderate to severe anthrax.


In order to identify contraindications, the doctor on the day of drug administration surveys and examines the patient with mandatory thermometry and setting an intradermal test with immunoglobulin, an anti-rhizomatic equine diluted 1: 100, to determine the sensitivity of the patient to the proteins of the horse's serum.
To this end, 0.1 ml of diluted 1: 100 immunoglobulin (ampoule marked in red) is injected intradermally into the area of ​​the flexor surface of the forearm. The reaction is taken into account after 20 minutes.
The sample is considered negative if the diameter of the papule does not exceed 0.9 cm, and the redness around it is not limited.
With a negative intracutaneous sample, 0.1 ml of the undiluted immunoglobulin of the antiparticular horse (the ampoule is marked in blue) is injected subcutaneously into the region of the middle third of the shoulder. In the absence of a local or general reaction after 30 minutes, intramuscularly injected into the upper outer quadrant of the buttocks fractional 2-3 times with an interval of 10-15 minutes the entire prescribed dose of the drug, after which the vaccine should be under the supervision of the doctor for one hour.
With a positive intradermal test, as well as in cases of development of an anaphylactic reaction to subcutaneous administration, an immunoglobulin, an antisibiric horse, a solution for intramuscular injection, is administered to patients only under vital signs under the supervision of a physician, with special precautions and only after preliminary intravenous administration of 90-120 mg of prednisolone.
It is recommended that the immunoglobulin protivosibirichevenny horse be injected under the skin first, diluted 1: 100, used for intradermal test, with an interval of 20 minutes in doses of 0.5 ml, 2 ml, 5 ml. In the absence of reaction to these doses, 0.1 ml of undiluted preparation is injected subcutaneously into the middle third of the shoulder region, in the absence of local or general reaction, after 30 minutes all the prescribed amount of the drug is fractionally administered.
The drug is not administered to patients with a positive intradermal test in the absence of life indications.
In cases of extremely severe form of the disease course and with sepsis, the immunoglobulin is injected into different places in the amount of 75-100 ml without determining the sensitivity and with intravenous administration of 90-120 mg of prednisolone. With the development of an anaphylactic reaction, it is necessary to carry out anti-shock measures.
The drug should be injected strictly aseptically intramuscularly into the gluteal region in a warmed to a temperature of 36-37 В° C.

For the purpose of emergency prophylaxis, immunoglobulin antiviral is administered once: adults - 20-25 ml, children, depending on their age - 5-8 ml, adolescents from 14 to 17 years - 12 ml.
The use of immunoglobulin for preventive purposes is not recommended in cases where it took more than 5 days after eating the meat of a sick animal or after possible infection of the skin.
With the therapeutic purpose the drug is injected immediately to establish the diagnosis of anthrax in combination with other methods of treatment (antibiotics, etc.) every day 30-50 ml for the moderate and severe course of the disease, and for extremely severe and sepsis - 75-100 ml during the first 3-4 days of illness.
With mild disease, administer the drug is not recommended.
In order to better absorb immunoglobulin in one place should be administered no more than 50 ml of the drug.


After the introduction of the immunoglobulin of an antisibiric horse, allergic forms of complications may develop: anaphylactic shock and serum sickness, and therefore it is necessary to provide medical supervision of patients within one hour after the injection.

Those who received the drug for preventive purposes should be warned about the need to urgently seek medical attention in case of fever, the appearance of symptoms characteristic of serum sickness.


The question of the use of the drug to persons suffering from allergic diseases and pregnant women should be decided by a doctor, taking into account the risk of possible infection with an anthrax pathogen.
These people, as well as previously received preparations containing horse serum protein, are recommended parenteral administration of one of the antihistamines before the introduction of the main dose of immunoglobulin of the antisibiric horse.

Reaction to administration: administration of the drug may be accompanied by local reactions (hyperemia, infiltration, soreness), the intensity of which depends on the individual characteristics of the patient.


Not installed.


For treatment-and-prophylactic and sanitary-and-iprophylactic institutions.


The preparation is stored and transported in accordance with SP at a temperature of 2 to 8 В° C.
Shelf life - 2 years.
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