Universal reference book for medicines
Name of the drug: DIMEDROL (DIMEDROL)

Active substance: diphenhydramine

Type: The blocker of histamine H 1 -receptors.
Anti-allergic drug
Manufacturer: ATOLL (Russia) produced by VEROPHARM (Russia)
Composition, form of production and packaging
The solution for intravenous and / or injection is
clear, colorless.

1 ml

Diphenhydramine 10 mg

1 ml - ampoules (10) - packs of cardboard.


Description of the drug approved by the manufacturer for the printed edition of 2011.


The blocker H 1 -gistaminovyh receptors of the first generation.
Action on the central nervous system is due to blockade of H 3 -histamine receptors in the brain and inhibition of central cholinergic structures. Removes spasm of smooth muscles (direct action), reduces permeability of capillaries, prevents and weakens allergic reactions, has local anesthetic, antiemetic, sedative effects, moderately blocks cholinergic receptors of vegetative ganglia, and has a hypnotic effect. Antagonism with histamine manifests itself in a greater degree in relation to local vascular reactions in inflammation and allergies than in systemic, ie. lowering blood pressure.However, with parenteral administration, patients with circulating blood volume deficiency may have lowered blood pressure and increased existing hypotension, due to ganglion blocking effects. In people with local brain damage and epilepsy activates (even in low doses) epileptic discharges on the electroencephalogram and can provoke an epileptic attack.
The action develops within a few minutes, the duration is up to 12 hours.


The connection with plasma proteins is 98-99%.
Penetrates through the blood-brain barrier. Metabolized mainly in the liver, in part - in the lungs and kidneys. It is excreted from the tissues after 6 hours. The half-life period is 4-10 hours. During the day, it is completely excreted by the kidneys in the form of metabolites conjugated with glucuronic acid. Essential amounts are excreted in milk and can cause sedation in infants (a paradoxical reaction characterized by excessive excitability may be observed).

- Anaphylactic and anaphylactoid reactions (in complex therapy);

Quincke's edema;

- serum sickness;

- other acute allergic conditions (in complex therapy and in cases when the use of a tablet form is impossible).


In / in or / m.

For adults and children older than 14 years in the / in or / m 1-5 ml (10-50 mg) 1% solution (10 mg / ml) 1-3 times a day;
the maximum daily dose is 200 mg.
For children aged 7 months to 12 months, 0.3-0.5 ml (3-5 mg), 1 to 3 years, 0.5-1 ml (5-10 mg), 4 to 6 years, 1-1.5 ml (10-15 mg), from 7 to 14 years of 1.5-3 ml (15-30 mg) if necessary every 6-8 hours.


From the nervous system: drowsiness, weakness, decreased speed of the psychomotor reaction, impaired coordination of movements, dizziness, tremor, irritability, euphoria, agitation (especially in children), insomnia.

On the part of the respiratory system: dryness of the mucous membrane of the mouth, nose, bronchi (increased viscosity of sputum).

From the hemopoiesis: hemolytic anemia, thrombocytopenia, agranulocytosis.

From the cardiovascular system: a decrease in blood pressure, tachycardia, extrasystole.

From the urinary system: violation of urination.

Allergic reactions: urticaria, photosensitivity, skin rash, itching.


- hypersensitivity to diphenhydramine;

- an angle-closure glaucoma;

- hyperplasia of the prostate;

- Stomach ulcer and duodenal ulcer complicated by stenosis;

- stenosis of the neck of the bladder;

- epilepsy;

- Children under 7 months.

Because of the risk of developing local necrosis, you can not use diphenhydramine as a local anesthetic.

With caution: bronchial asthma, pregnancy, lactation.


Take with caution during pregnancy and lactation.


Contraindicated: children under 7 months.


During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions (driving a car, etc.).

During treatment with diphenhydramine, UV radiation and the use of ethanol should be avoided.


Symptoms: oppression or excitation (especially in children) of the central nervous system, depression.
Other symptoms of an overdose resemble the action of atropine: dilated pupils, dry mouth, upset of the functions of the gastrointestinal tract.
Treatment: there is no special antidote.
Gastric lavage. Control of blood pressure. Symptomatic therapy includes drugs that increase blood pressure, oxygen, the introduction of plasma-substituting fluids in / in.
You can not use adrenaline and analeptics.


Strengthens the action of ethanol and drugs (LS), depressing the central nervous system.

Inhibitors of monoamine oxidase (MAO) increase the anticholinergic activity of diphenhydramine.

Antagonistic interaction is noted when co-administered with psychostimulants.

Reduces the effectiveness of apomorphine as a vomiting drug in the treatment of poisoning.

It enhances the anticholinergic effects of drugs with m-cholinoblocking activity.


The drug is released by prescription.


List B.

The drug should be stored in a place protected from light, inaccessible to children, at a temperature of no higher than 30 В° C.

Shelf life 5 years.

Do not use after the expiration date.

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