Universal reference book for medicines
Name of the preparation: BENFOGAMMA® 150 (BENFOGAMMA 150)

Active substance: benfotiamine

Type: Fat-soluble form of vitamin B 1

Manufacturer: WOERWAG PHARMA (Germany) manufactured by MAUERMANN ARZNEIMITTEL (Germany)
Composition, form of production and packaging
The tablets covered with a cover of
white color, shining, round, biconcave.

1 tab.

benfotiamine 150 mg

Excipients: cellulose microcrystalline - 122 mg, povidone K30 - 8 mg, glycerides of fatty acids - 5 mg, silicon dioxide colloid - 7 mg, carmellose sodium - 3 mg, talc - 10 mg.

The composition of the shell: shellac - 3 mg, sucrose - 70.875 mg, calcium carbonate - 66.479 mg, talc - 41.314 mg, acacia gum - 10.155 mg, corn starch - 7.34 mg, titanium dioxide - 10.932 mg, silicon colloidal dioxide - 4.404 mg, povidone K30 - 6.21 mg, macrogol 6000 - 1.597 mg, glycerol 85% - 2.262 mg, polysorbate 80 - 0.133 mg, wax mountain glycolic - 0.3 mg.

15 pcs.
- blisters (2) - packs of cardboard.
15 pcs.
- blisters (4) - packs of cardboard.

Description of the drug approved by the manufacturer for the printed edition of 2015.


Vitamin preparation.
Benzothiamine is a fat soluble thiamine derivative (vitamin B 1) . Thiamine is converted to an active thiamine pyrophosphate and as a coenzyme is included in the pyruvate decarboxylase, alpha-ketoglutarate decarboxylase complex, which participate in the oxidative decarboxylation of pyruvic and alpha-ketoglutaric acids; transketolase - an enzyme of the pentose phosphate shunt.

Suction and distribution

Absorption is high, all over the small intestine.
Before absorption, it is released from the bound state by digestive enzymes. After 15 minutes it is found in the blood, after 30 minutes - in other tissues.
In the blood, the concentration is relatively low, with a predominantly free thiamin circulating in the plasma, in its erythrocytes and leukocytes, its phosphoric esters.

Metabolism and excretion

Phosphorylation occurs in the liver.
The most active phosphoric ester is thiamine diphosphate, which has coenzyme activity. It accumulates mainly in the liver, heart, brain, kidneys, spleen. 1/2 of the total amount is contained in striated muscles and myocardium and about 40% in internal organs.
It is excreted through the intestines and kidneys.


Deficiency of vitamin B 1 , confirmed by clinical and biochemical research, developing against the background:

- Inadequate and malnutrition (beriberi disease);

parenteral nutrition for a long time;

- hemodialysis;

- chronic alcoholism (alcoholic cardiomyopathy, Wernicke's encephalopathy, Korsakov's syndrome);

- increased demand for vitamin B 1 .

Polyneuropathies due to vitamin B deficiency 1 .
Typical signs of this deficiency are neurological disorders in the form of neuropathies with sensory disorders (pain, tingling sensation, loss of sensitivity in the upper and lower extremities).

For the treatment of vitamin B deficiency 1 appoint 1 tab.
1 time / day.
For treatment of polyneuropathies caused by a deficiency of vitamin B 1, the initial dose is 1 tablet.
2 times / day for 3 weeks, then appoint 1 tab. daily.
The duration of treatment depends on its effectiveness and is determined by the doctor.

The tablet is taken without chewing, with a small amount of water.


Allergic reactions: angioedema, hives, itching.


- deficiency of sugar / isomaltase, intolerance to fructose, glucose-galactose malabsorption;

- Pregnancy;

- childhood;

- increased individual sensitivity to the components of the drug.


Pregnancy is a contraindication for the use of the drug.


Contraindicated in children


In elderly people, there were no adverse reactions other than those mentioned above.


In elderly people, there were no adverse reactions other than those mentioned above.

It is not recommended to take a double dose of the drug if the previous dose was missed.

With encephalopathy Wernicke, the administration of thiamine should be preceded by the administration of dextrose.

Influence on the ability to manage vehicles and mechanisms

There is no evidence of the effect of the drug used in therapeutic doses on the ability to drive vehicles and mechanisms.


An overdose of the preparation BENFOGAMMA ® 150 has not been observed to date.


Thiamine weakens the effect of depolarizing muscle relaxants (suxamethonium iodide and others), is inhibited by fluorouracil.

Ethanol slows the rate of absorption of thiamine after oral administration.


The drug is released by prescription.


The drug should be stored out of reach of children at a temperature of no higher than 25 ° C.
Shelf life - 5 years.
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