Universal reference book for medicines
Product name: ALERPRIV (ALERPRIV)

Active substance: loratadine

Type: The blocker of histamine H 1 -receptors.
Anti-allergic drug
Manufacturer: QUIMICA MONTPELLIER (Argentina) BAGO GROUP COMPANY (Argentina)
Description of the active substance :.
This information is a reference and it is not enough that the drug was prescribed by a doctor.
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PHARMACHOLOGIC EFFECT
The blocker of histamine H 1 -receptors.
Has antiallergic, antipruritic, antiexudative action. Reduces the permeability of capillaries, prevents the development of edema of tissues, reduces the increased contractile activity of smooth muscles, due to the action of histamine.
PHARMACOKINETICS
When administered orally at a therapeutic dose, loratadine is rapidly absorbed from the gastrointestinal tract and almost completely metabolized in the body.
C maxloratadine in plasma is achieved after 1-1.3 h, the main active metabolite, descarbotoxyloratadine, - after about 2.5 h.
With simultaneous intake of food, the bioavailability of loratadine and descarbonethoxyloratadine increases by approximately 40% and 15%, respectively, the time to reach C max increased by about 1 hour, its values ​​for these substances remained unchanged.

The binding with plasma proteins of loratadine is high - about 98%, active metabolite - less pronounced.

On the average, Tl 1/2 loratadine is 8.4 h, descarbethoxytoloratadine is 28 h (8.8-92 h).

About 80% of loratadine is excreted in the form of metabolites with urine and feces in equal proportions for 10 days, about 27% - with urine during the first day.

INDICATIONS
Seasonal and all-the-year-round allergic rhinitis, conjunctivitis, acute urticaria and Quincke's edema, symptoms of histaminergia caused by the use of histaminoliberates (pseudoallergic syndromes), allergic reactions to insect bites, complex treatment of itching dermatoses (contact allergic dermatitis, chronic eczema).

DOSING MODE
Inside adults and children over 12 years of age, as well as with a body weight of more than 30 kg - 10 mg 1 time / day.

Children from 2 to 12 years with a body weight of less than 30 kg - 5 mg 1 time / day.

SIDE EFFECT
On the part of the digestive system: rarely - dry mouth, nausea, vomiting, gastritis;
in some cases - violations of the liver.
From the side of the central nervous system: rarely - increased fatigue, headache, excitability (in children).

From the cardiovascular system: rarely - tachycardia.

Allergic reactions: rarely - skin rash;
in isolated cases - anaphylactic reactions.
Dermatological reactions: in some cases - alopecia.

CONTRAINDICATIONS
Pregnancy, lactation, children under 2 years, hypersensitivity to loratadin.

PREGNANCY AND LACTATION
Loratadine should not be used during pregnancy and lactation.

In experimental studies on animals, loratadine did not adversely affect the fetus in medium doses, and some fetotoxic effects were observed at high doses.

APPLICATION FOR FUNCTIONS OF THE LIVER
Patients with impaired renal or hepatic function require a correction of the dosing regimen.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Patients with impaired renal or hepatic function require a correction of the dosing regimen.

APPLICATION FOR CHILDREN
Contraindicated in children up to 2 years.

SPECIAL INSTRUCTIONS
The use of loratadine can not completely exclude the development of seizures, especially in predisposed patients.

Patients with impaired renal or hepatic function require a correction of the dosing regimen.

DRUG INTERACTION
With the simultaneous use of loratadine with drugs that inhibit the isoenzymes CYP3A4 and CYP2D6 or are metabolized in the liver with their participation (including cimetidine, erythromycin, ketoconazole, quinidine, fluconazole, fluoxetine), it is possible to change the concentration in blood plasma of loratadine and / or these preparations.

Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, zixorin, rifampicin, phenylbutazone, tricyclic antidepressants) reduce effectiveness.


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