Universal reference book for medicines
Name of the preparation: AKRIDERM В® GK (AKRIDERM GK)

Active substance: betamethasone dipropionate, clotrimazole, gentamicin

Type: The drug with antibacterial, antifungal and anti-inflammatory action for external use

Manufacturer: Chemical-Pharmaceutical Plant Akrihin (Russia)
Composition, form of production and packaging
?
Cream for external use in white or almost white.
100 g

betamethasone dipropionate 64 mg

clotrimazole 1 g

gentamicin (in the form of sulfate) 100 mg

Excipients: Vaseline - 15 g, propylene glycol - 10 g, paraffin liquid - 6 g, cetostearyl alcohol (cetyl alcohol 60%, stearyl alcohol 40%) - 7.2 g, macrogol cetostearate (macrogol-20 cetostearyl ether) 2.3 g, disodium edetate - 500 mg, sodium dihydrogen phosphate dihydrate - 260 mg, purified water - up to 100 g.

15 g - aluminum tubes (1) - cardboard packs.

30 g - aluminum tubes (1) - cardboard packs.

?
Ointment for external use white or almost white, translucent.
100 g

betamethasone dipropionate 64 mg

clotrimazole 1 g

gentamicin (in the form of sulfate) 100 mg

Excipients: propyl parahydroxybenzoate (nipazole), paraffin liquid (vaseline oil), isopropyl myristate, petroleum jelly.

15 g - aluminum tubes (1) - cardboard packs.

30 g - aluminum tubes (1) - cardboard packs.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2016.

PHARMACHOLOGIC EFFECT

Combination drug for external use with anti-inflammatory, anti-allergic, antifungal and antibacterial action.

Gentamicin is an antibiotic of a broad spectrum of bactericidal action from the group of aminoglycosides, highly active against Gram-negative bacteria Proteus spp.(indole-positive and indole-negative strains), Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp., Staphylococcus spp.
(methicillin-resistant). It is active against Serratia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp. Gentamycin is resistant to: Neisseria meningitidis, Treponema pallidum, anaerobic microorganisms (Streptococcus spp. (Except Streptococcus pneumoniae), Providencia rettgeri).
Betamethasone has anti-inflammatory, anti-allergic, anti-exsudative action.

Clotrimazole is an antifungal agent from the group of imidazole derivatives.
It has an effect due to a disruption in the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Has a wide range of action. It is active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast and mold fungi (Candida albicans, Turolopsis glabrata, Rhodotorula spp., Pityrosporum orbiculare).
PHARMACOKINETICS

With external use of the drug in therapeutic doses, transdermal absorption of active substances into the blood is very small.
When applied to the skin, the intensity of absorption of betamethasone depends on the state of the epidermal barrier (inflammation and skin diseases increase absorption).
The use of occlusive dressings increases the transdermal absorption of betamethasone and gentamicin, which can lead to an increased risk of systemic side effects.

INDICATIONS

- dermatitis simple and allergic (especially complicated secondary infection);

- diffuse neurodermatitis (including atopic dermatitis);

- limited neurodermatitis (including simple chronic lichen);

- eczema;

- dermatomycosis (dermatophytosis, candidiasis, multicolored lichen), especially when localized in the groin and large folds of the skin.

DOSING MODE

The drug is used externally.

Cream or ointment applied to the affected skin in a small amount, lightly rubbing, 2 times / day.
The duration of treatment is determined individually and depends on the nosological form and severity of the disease. In the case of dermatomycosis, the average duration of treatment is 2-4 weeks.
If clinical improvement does not occur in the near future, it is necessary to clarify the diagnosis or change the treatment regimen.

SIDE EFFECT

Local reactions: itching, burning sensation, irritation, dry skin, folliculitis, hypertrichosis, steroid acne, hypopigmentation, allergic reactions.
When using occlusive dressings - maceration, infection, skin atrophy, striae, sweating.
Systemic reactions: prolonged treatment or application to extensive skin surfaces - weight gain, osteoporosis, increased blood pressure, swelling, ulceration of the gastrointestinal mucosa, exacerbation of hidden foci of infection, hyperglycemia, agitation, insomnia, dysmenorrhea.

CONTRAINDICATIONS

- Tuberculosis of the skin;

- cutaneous manifestations of syphilis;

- chickenpox;

- Herpes simplex;

- skin postvaccinal reactions;

- open wounds;

- Children under 2 years;

- Hypersensitivity to the components of the drug.

Caution should be used during pregnancy, especially in the first trimester, in children aged 2 to 18 years.

PREGNANCY AND LACTATION

In pregnancy (especially in the first trimester), the use of the drug is allowed only in cases where the intended use for the mother exceeds the potential risk to the fetus.
In such cases, the use of the drug should be short and limited to small areas of skin.
It is not known whether the components of the drug are excreted in breast milk.
Therefore, if you need to use the drug Acriderm В® HA during lactation should stop breastfeeding.
APPLICATION FOR CHILDREN

Contraindicated use of the drug in childhood to 2 years.

Caution should be used in children aged 2 to 18 years.

Due to the fact that in children the area of ​​the skin with respect to body weight is higher than in adults, and the epidermis is not sufficiently developed, with external application of the drug it is possible to absorb proportionally more active substances and, consequently, there is a greater risk of systemic adverse reactions , as well as atrophic skin changes.
Use the drug in children should be as short as possible and with all precautions.
SPECIAL INSTRUCTIONS

Avoid contact with the eyes.

When there is a stable bacterial or fungal microflora, it is necessary to cancel the drug and prescribe the appropriate therapy.

Use in Pediatrics

Due to the fact that in children the area of ​​the skin with respect to body weight is higher than in adults, and the epidermis is not sufficiently developed, with external application of the drug it is possible to absorb proportionally more active substances and, consequently, there is a greater risk of systemic adverse reactions .
Use the drug in children should be as short as possible and with all precautions.
OVERDOSE

Symptoms: with excessive or prolonged use of the drug may develop symptoms of hypercorticoidism.

Treatment: gradual withdrawal of the drug, symptomatic therapy, if necessary - correction of electrolyte disorders.

DRUG INTERACTION

Interaction of Acriderm GK with other drugs has not been established.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of reach of children at a temperature of 15 В° to 25 В° C.
Shelf life - 2 years.

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