TFCS.
This information is a reference and it is not enough that the drug was prescribed by a doctor. .
PHARMACHOLOGIC EFFECT
Combined drug.
Acetylsalicylic acid has antipyretic and anti-inflammatory effect, relieves pain, especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and thrombosis, improves microcirculation in the inflammatory focus.
Caffeine increases the reflex excitability of the spinal cord, excites the respiratory and vasomotor centers, dilates the blood vessels of skeletal muscles, brain, heart, kidneys, reduces platelet aggregation; reduces drowsiness, a feeling of fatigue, increases mental and physical performance. In this combination, caffeine in a small dose has practically no stimulating effect on the central nervous system, but it helps to normalize the tone of the vessels of the brain and accelerate blood flow.
Paracetamol has an analgesic, antipyretic and extremely weak anti-inflammatory effect, which is related to its effect on the thermoregulatory center in the hypothalamus and a weak ability to inhibit the synthesis of prostaglandins in peripheral tissues.
INDICATIONS
Pain syndrome of mild to moderate severity (of different origins):
- headache;
- Migraine;
- toothache;
- neuralgia;
- myalgia;
- Arthralgia;
- algodismenorea.
Feverish syndrome:
- with ARI;
- with the flu.
DOSING MODE
Inside (during or after a meal) 1 tab. every 4 hours, with pain syndrome - 1-2 tablets; the average daily dose is 3-4 tablets, the maximum daily dose is 8 tablets. The course of treatment is no more than 7-10 days.
The drug should not be taken more than 5 days as an analgesic and more than 3 days - as an antipyretic agent (without appointment and supervision of a doctor).Other dosages and schedules are prescribed by the doctor.
SIDE EFFECT
Gastralgia, nausea, vomiting, hepatotoxicity, nephrotoxicity, erosive-ulcerative lesions of the gastrointestinal tract, allergic reactions (including Stevens-Johnson syndrome, Lyell), tachycardia, increased blood pressure, bronchospasm.
With prolonged use - dizziness, headache, visual disturbances, tinnitus, reduced platelet aggregation, hypocoagulation, hemorrhagic syndrome (epistaxis, bleeding gums, purpura, etc.), kidney damage with papillary necrosis; deafness; Reye's syndrome in children (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, liver dysfunction).
CONTRAINDICATIONS
hypersensitivity;
- erosive-ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation);
- gastrointestinal hemorrhage;
- "aspirin" asthma;
- hemophilia;
- hemorrhagic diathesis;
- hypoprothrombinemia;
- portal hypertension;
- avitaminosis K;
- kidney failure;
- Pregnancy (I and III trimesters);
- lactation period (breastfeeding);
- deficiency of glucose-6-phosphate dehydrogenase;
- severe arterial hypertension;
- severe course of ischemic heart disease;
- glaucoma;
- increased excitability;
- sleep disorders;
- surgical interventions accompanied by bleeding;
- Children's age (under 15 years - the risk of developing Reye's syndrome in children with hyperthermia in the presence of viral diseases).
With caution: gout, liver disease.
PREGNANCY AND LACTATION
Contraindicated in pregnancy (I and III trimesters), during lactation.
Acetylsalicylic acid has a teratogenic effect; when applied in the first trimester of pregnancy leads to malformations - the cleavage of the upper palate; in the third trimester - to inhibition of labor (inhibition of the synthesis of prostaglandins), to the closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the small circle of blood circulation.
Isolated with breast milk, which increases the risk of bleeding in the child due to impaired platelet function.
APPLICATION FOR FUNCTIONS OF THE LIVER
Contraindicated in renal failure.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
With caution: liver disease.
APPLICATION FOR CHILDREN
Children under 15 years of age should not be prescribed medications containing acetylsalicylic acid, since in the case of a viral infection they can increase the risk of developing Reye's syndrome. Symptoms of Reye's syndrome include prolonged vomiting, acute encephalopathy, and enlargement of the liver.
SPECIAL INSTRUCTIONS
Children should not be prescribed drugs containing acetylsalicylic acid, since in the case of a viral infection they can increase the risk of developing Reye's syndrome. Symptoms of Reye's syndrome include prolonged vomiting, acute encephalopathy, and enlargement of the liver.
With continued use of the drug, control of peripheral blood and the functional state of the liver is necessary.
Since acetylsalicylic acid slows blood clotting, the patient, if he is to undergo surgery, must warn the doctor in advance about taking the drug.
Patients with hypersensitivity or with asthmatic reactions to salicylates or their derivatives acetylsalicylic acid can be prescribed only with special precautions (in emergency services).
Acetylsalicylic acid in low doses reduces the excretion of uric acid. In patients with a corresponding predisposition, this can in some cases provoke a gout attack.
During treatment should be abandoned the use of ethanol (increased risk of gastrointestinal bleeding).
Acetylsalicylic acid has a teratogenic effect; when applied in the first trimester of pregnancy leads to malformations - the cleavage of the upper palate; in the third trimester - to inhibition of labor (inhibition of prostaglandin synthesis), to the closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the small circulation.
Isolated with breast milk, which increases the risk of bleeding in the child due to impaired platelet function.
OVERDOSE
Symptoms (due to acetylsalicylic acid): with light intoxication - nausea, vomiting, gastralgia, dizziness, ringing in the ears; severe intoxication - retardation, drowsiness, collapse, convulsions, bronchospasm, shortness of breath, anuria, bleeding. Initially, central hyperventilation of the lungs leads to respiratory alkalosis (dyspnea, choking, cyanosis, sweating). With increasing intoxication, progressive paralysis of respiration and dissociation of oxidative phosphorylation cause respiratory acidosis.
Treatment: constant monitoring of acid-base balance and electrolyte balance; depending on the state of metabolism - the introduction of sodium bicarbonate, sodium citrate or sodium lactate. Increased reserve alkalinity increases the excretion of acetylsalicylic acid due to alkalinization of urine.
DRUG INTERACTION
Strengthens the action of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic drugs.
Simultaneous administration with other NSAIDs, methotrexate increases the risk of side effects.
Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, as well as anti-arthritis drugs that promote the excretion of uric acid.
Barbiturates, rifampicin, salicylamide, antiepileptic drugs and other stimulants of microsomal oxidation contribute to the formation of toxic metabolites of paracetamol, which affect liver function.
Metoclopramide accelerates the absorption of paracetamol.
Under the influence of paracetamol, T 1/2 chloramphenicol increases by 5 times. With repeated admission, paracetamol can enhance the effect of anticoagulants (dicumarin derivatives).
Simultaneous reception of paracetamol and ethanol increases the risk of hepatotoxic effects.
Caffeine accelerates the absorption of ergotamine.
