TFCS.
This information is a reference and it is not enough that the drug was prescribed by a doctor. .
PHARMACHOLOGIC EFFECT
Monocyclic beta-lactam antibiotic. The nucleus of the molecule is alpha-methyl-3-amino-mono-bactamic acid. Suppresses the synthesis of the cell wall, acts bactericidal, resistant to beta-lactamases of gram-negative bacteria. It is active against gram-negative aerobic pathogens (Salmonella spp., Shigella spp., Proteus spp., Escherichia coli, Klebsiella spp., Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Pseudomonas aeruginosa, Entero-Citrobacter spp.), Does not act on Gram-positive microorganisms and anaerobes. Possible appointment with allergies to penicillins, cephalosporins and carbapenems. Between the aztreonam and aminoglycosides, there is cross-resistance. Rarely causes dysbacteriosis.
PHARMACOKINETICS
With the / m introduction, absorption is fast. T max - 1 h. C max - after intravenous administration 0.5, 1 and 2 g - 54, 90 and 204 Ојg / ml, respectively. Passes histohematological barriers and penetrates well into tissues. T 1/2 - 1.7 hours (with normal kidney function), if the excretory function is impaired and in old age - lengthens. It penetrates through the BBB during inflammation of the meninges, penetrates the placenta, is excreted in breast milk. It is slightly metabolized in the liver.60-75% is excreted by the kidneys unchanged, 12% - with bile. With hemodialysis, the concentration in the blood decreases by 30-60%.
INDICATIONS
- sepsis;
- endocarditis;
- meningitis;
- peritonitis;
- infections of the lower respiratory tract (pneumonia, lung abscess, pleural empyema, bronchitis);
- Gastrointestinal tract infections;
- bile duct infection (cholangitis, cholecystitis, enterocolitis);
- infections of the kidneys and urinary tract, urogenital area (pyelonephritis, urethritis, cystitis, endometritis);
- Gonorrhea;
- infections of bones, skin and soft tissues;
- localized parenchymatous abscesses;
- infected burns and wounds;
- infection or threat of infection in patients with reduced immunity;
- Postoperative infections (including prevention).
DOSING MODE
In / m, in / in streamwise and drip.
When pyelonephritis and infections of the urinary tract are prescribed in / m 0.5-1 g 2-3 times a day.
For systemic infections of moderate -to- moderate course , 1-2 g 2-3 times a day; with systemic infections of severe course - 2 g 2-4 times a day. The maximum daily dose is 8 g.
In the treatment of acute uncomplicated gonorrhea and acute uncomplicated cystitis - once per / m 1 g.
With sepsis, peritonitis is injected / in; for jet intravenous administration the preparation is dissolved in 6-10 ml of water for injection; injected for 3-5 minutes; for intravenous drip infusion 1 g of the drug is dissolved in 3 ml of water for injection and diluted in 50-100 ml of 0.9% sodium chloride solution.
Children over the age of 9 months are prescribed 30 mg / kg 3-4 times / day; children older than 2 years with severe infections - 50 mg / kg 3-4 times / day.
In chronic renal failure (KK 10-30 ml / min), appoint half the average single dose.
SIDE EFFECT
Allergic reactions: skin rash, skin itching, multi-form exudative erythema, petechia, urticaria.
From the digestive system: diarrhea, nausea, vomiting, stomatitis, taste change, candidamycosis.
From the nervous system: convulsions, diplopia, insomnia, dizziness, headaches, confusion.
From the musculoskeletal system: myalgia, arthralgia.
Laboratory indicators: eosinophilia, thrombocytopenia, increased prothrombin time, anemia, neutropenia, increased activity of "liver" transaminases (ALT and AST) and APF.
Local reactions : with iv administration - phlebitis, thrombophlebitis, unpleasant sensations at the site of the / m administration.
Other: swelling of the mammary glands, increased sweating.
CONTRAINDICATIONS
hypersensitivity;
- chronic renal failure (CC less than 10 ml / min);
- liver failure;
- Pregnancy;
- lactation period;
- Children's age (up to 9 months).
C with caution: allergic reactions to other beta-lactam antibiotics in the anamnesis.
PREGNANCY AND LACTATION
Contraindicated in pregnancy and lactation.
APPLICATION FOR FUNCTIONS OF THE LIVER
Contraindicated in chronic renal failure (CC less than 10 ml / min).
In chronic renal failure (KK 10-30 ml / min), appoint half the average single dose.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Contraindicated in liver failure.
APPLICATION FOR CHILDREN
Contraindicated in childhood to 9 months.
Children over the age of 9 months are prescribed 30 mg / kg 3-4 times / day; children older than 2 years with severe infections - 50 mg / kg 3-4 times / day.
OVERDOSE
Symptoms: polymorphic nonspecific manifestations.
Treatment : symptomatic, hemo- or peritoneal dialysis.
DRUG INTERACTION
Pharmaceutically incompatible with heparin and metronidazole. It has a synergistic effect with vancomycin, clindamycin, aminoglycosides, penicillins, cephalosporins, carbapenems, metronidazole.