Zafirlukast (zafirlukast)


ZAFIRLUKAST (Zafirlukast).
     N-G (5-methyl Tsiklopentiloksikarbonilamino-1- metilindol-3- mud) -3 - metoksi-3- tolilsulfonilbenzamid.
     Synonym : Akolat, Acolate.
     White or pale yellow amorphous powder. Almost nerastvorim water, easily soluble in dimetilsulfokside, acetone and tetrahydrofuran.
     Synthetic drugs-selective receptor blockers leykotrienovyh (at prostaglandinovye, tromboksanovye, gistaminovye holinergicheskie receptors and does not have a significant impact). Prevents increase vascular permeability and infiltration Eosinophils inhaled, caused by the most active and provospalitelnymi bronhosuzhivayuschimi leykotrienami peptide (LTS4, LTD4, LTE4); Reduces the cellular vnekletochnyh factors and inflammatory responses in the respiratory tract, induced antibodies.
     The drug prevents or reduces bronchospasm due to the different types of provocation; Physical stress, cold air, various antibodies (pollen plants, etc.).
     Once inside quickly and completely absorbed, C max is 3 hours; T? 10-h; under intense biotransformation, displayed kidneys.
     Assign to prevent attacks of asthma and maintenance treatment, including after cupping the stimulants? - Adrenoreceptor. Using the drug can decrease the need for? - Adrenostimulyatorah.
     Applied inside (to avoid a deterioration of aspiration should not be taken with meals).
     Adults appointed from 0.02 g (1 tablet), 2 times a day. Normal intake is maintained in the future also one pill two times a day. Is the preparation of long-term (as a preventive tool). If necessary (lack of effect) dose gradually increased to 0.08 g 2 times a day (maximum dose).
     The drug is usually well. There headache, vomiting, abdominal pain, allergic reactions.
     Determinations of hypersensitivity to the drug continue to receive his stop. There should be appointed zafirlukast (in the absence of appropriate life) pregnant and nursing mothers. The safety of the drug for children under the age of 12 years have not been established.
     Like other newly introduced practice LS, zafirlukast be applied under close medical supervision.
     Product : pills to 0.02 and 0.04 g (20 and 40 mg) (N. 14, 28, 56).
     Storage : List B.

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