KSANTINOLA NIKOTINAT (Xantinoli nicotinas). 7-[2-Oksi-3- (N-methyl-oksietilamino b) - propyl] - teofillina nikotinat.

     The white crystalline powder, readily soluble in water, dry in alcohol.

     Synonyms : Komplamin, Ksavin, Sadamin, Teonikol, Angioamin, Complamex, Complamin, Contamex, Mehemin, Sadamin, Teonicol, Vedrin, Xantinol nicotinate, Xavin etc.

     The drug combines the properties of substances group teofillina and nicotinic acid (see).

     Expands peripheral vessels, kollateralnoe improves peripheral circulation, cerebral blood circulation and reduces cerebral hypoxia phenomenon, improves receptacles mesh shell eyes. Decreases aggregation of platelets. Like teofillinu increases of the heart.

     Applied ksantinola nikotinat with obliteriruyuschem atherosclerosis vascular lower limbs, peremezhayuscheysya limp, Reino disease, diabetes angiopatii, retinopathy, poorly healing trophic ulcer lower limbs, as well as violations ateroskleroticheskih cerebral circulation, migraines, Menera syndrome. The drug increases the brain blood flow and improves metabolic processes in the brain aftercare period after the removal of brain tumors, brain injuries, etc. (There is evidence that when intravenously komplamina, brain vessels increases only briefly, and yet difficult drain blood in the brain vein. Therefore, the preparation should not be used in intrakranialnyh stagnation, and where contraindicated increased pulse fluctuations vascular brain.) .

     Also available on ksantinola nikotinata Medicine at some of the trophic vascular disorders of the (sclerodermia, neyrodermit etc.).

     Assign drug inside, intramuscularly or intravenously.

     Inside are from 1 pill (to 0.15 g) three times a day after meals; If necessary dose increased to 2 to 3 tablets three times a day. Pills proglatyvayut not liquid. As the state to reduce the dose of 1 tablet 2 to 3 times a day. The course of treatment is usually 2 months.

     In severe violations of blood tissue type intramuscularly to 2 ml 15% solution (1 vials containing 0.3 g product), 1 to 3 times a day with a gradual increase in doses up to 0.6 - 0.9 grams (4-6 ml 15% solution) 2 - 3 times daily. The length of treatment depends on the particular case (2 - 3 weeks).

     In severe violations of peripheral and cerebral circulation injected (slowly!) 2 ml 15% solution of 1 to 2 times a day; Then move on intramuscular injections (1 ml for 2 to 3 times a day); Once appointed interior to 2 pills three times a day.

     In severe cases, medication can be administered by intravenous drip also. for this to throw 10 ml 15% solution (1, 5 g) in 200 or 500 ml of 5% glucose solution and isotonic sodium chloride solution. Enter within 1 - 4 hours to 4 times a day. The duration of treatment 5 to 10 days.

     In applying ksantinola nikotinata, especially in the employment shock and parenteral introduction, can sense heat, tingling and redness of skin upper body (head and neck), weakness, dizziness, feeling pressure in his head (See also nicotinic acid). . These phenomena are expressed especially when the patient upright. When intravenously can develop severe hypotension, and therefore in this kind of introduction, the patient must be in a horizontal position.

     When ingestion during or after eating expressed little side effects. Are they usually after 10 to 20 minutes.

     Contraindications : acute myocardial infarction, heart failure II B-III level, acute haemorrhage.

     Do not apply ksantinola nikotinat in the first three months of pregnancy. To avoid abrupt AD should not appoint him while hypotensive drugs and strofantinom. If necessary, simultaneous use of cardiac glycosides, in order to prevent the development of aetiology and adults, the treatment must be conducted under the supervision of the ECG. Caution must be exercised in patients with unstable AD, stomach ulcers (acute stage).

     Method of issuance : pills (pills) containing 0.15 grams of the drug; 15% solution in 2 ml ampoules (to 0.3 g) and 10 ml (1, 5 g to a drip).

     Storage : List B. In the dark spot.

     Recently invited to apply ksantinola nikotinat as a reflex to treat alcoholism. The reason for this is caused by drug side effects (effects of nicotinic acid).

     This ksantinola nikotinat impose intramuscularly dose 0,15 0,3 g (1 - 2 mL of 15% solution). Dose picked indivilualno that appeared effect (Blush skin, dizziness, etc.), in which the patient offer bicycle vodka and poloskat her mouth. The procedure for each day during the 10 to 15 days before a uslovnoreflektornogo aversion to alcohol. During the procedure can be ksantinola nikotinata period (10 to 30 minutes) to make short breaks (1 to 2 minutes) in the reception alcohol.

     Treatment must be carried out under the close supervision of a doctor.

Materials allowed to copy only with the active hyperlink to the handbook of medicines