Urea (urea pura)

	Urea (urea pura) UREA (Urea pura). Synonyms : Karbamid, Carbamid, Carbamidum, Ureaphil. The white crystalline powder or colourless crystals solonovato- bitter taste, and odourless. Easily rastvorima water (1 : 1), rastvorima in alcohol (1 : 5). Aqueous solutions are neutral reaction. NEW water happens to absorb heat. Wash used in the past as diureticheskogo funds. Her appointed interior (usually sugar or fruit syrup) and 15 - 20 g per reception 2 to 5 times a day. In these doses, it has diuretichesky effect, but violations of kidney function can dramatically increase the nitrogen content in the body. Diuretichesky effects associated with the operation of many molecules of urea; In the body, they are not filtered and exchange processes in a large number (50-60%) through klubochki without blowing it back. The high osmotic pressure created in the Channel, is a strong water Diurez. Currently, the emergence of new efficient diureticheskih of urea for this purpose does not apply. Apply appointed mainly as degidratiruyuschego means to prevent and reduce brain swelling and swelling of toxic lungs, as well as a powerful tool depressing inner pressure. Anti effect and mechanism of anti-hypertensive (against vnutriglaznamu pressure) urea is not clear. It is expected that the important role played by osmotic effect. The sharp increase in osmotic pressure of blood caused by the introduction of PNDS urea solutions, leading to strong earnings in the blood leaking into tissues and organs, and including cavity and brain and eye tissue. �� ; �� , �� , � �� , � �� - � ��. Anti-hypertensive effect for vnutricherepnogo and inner pressure is not directly linked to diureticheskim action. It was found that in a pilot anti-hypertensive effect persists after bilateral nefrektomii. But diuretichesky effect contributes to lower pressure. There is also evidence to believe that a role in the anti-hypertensive effect played the central mechanisms (hypertonic solution to the influence osmoretseptivnye fields in the hypothalamus). Urea been used in neurosurgery to prevent and reduce swelling of the brain, especially in the early stages of its development. In ophthalmic practice urea appointed to glaucoma, especially during the acute attack, as well as the preparation of patients with high oftalmotonusa operations. Urea applied intravenously, as well as inside. For intravenous use specially purified, sterile, dried product urea, called Urea injection (Urea pro injectionibus). Impurities biureta and ammonia in the raw products may cause hemolysis erythrocytes. Abroad intravenous infusions produced refined urea solution inverted sugar under nazvzniem "Urevert." Urea Solution intravenous train just before the introduction of aseptic conditions. When standing solutions decompose and can cause hemolysis. Implements 30% solution, prepared by 10% glucose solution. NEW happens to the heat sink (liquid cooled). Solution stand until it reaches room temperature. Enter drip solution at the speed of 40-60-80 drops per minute. Only if it is necessary for quick and maximum effect increases the speed of 80 to 120 drops per minute. The total dose of 0.5 to 1, 5 grams (about 1 g) of urea per 1 kg of body weight patient. The effect is usually within 15 to 30 minutes, reaching a maximum of 1 to 1, 5 h from the start of the solution and lasted 5 to 6 hours or more (up to 14 h). You can re-enter (no more than 2 to 3 times) and an 12-24 h. When the brain swelling had reduced vnutricherepnogo pressure, reduce the stress of hard brain lining, a ripple; If glaucoma is to reduce inner pressure Inside appointed urea as 50% or 30% solution of sugar syrup dose of 0,75-1, 5 g / kg. There is evidence that the anti-hypertensive effect of glaucoma after oral application of urea is at the same time (30-45 minutes), and that intravenous drip introduction. However, degidratiruyuschee effect on the brain tissue is the oral introduction only a few hours. Subject to the necessary rules of urea no complications do not change rates of blood and urine. In the first few hours was increased residual nitrogen in the blood, then quickly return to the original figures. In some cases, intravenous increases AD. In connection with the dehydrated patients suffer thirst and dry mouth. �� (500 - 800 ��) � �� (0,2 - 0,3 �) � �� 1 (0,1 - 0.15 g). Diuretics not assign patients. In infusion solution of urea patients are unconscious or under anaesthesia, to provide urine should be put in the bladder catheter. When intravenously should not be allowed into the solution under the skin to avoid irritation and tissue necrosis. In some cases, intravenously, can be monitored and limited venous thrombosis flebity. For admission into possible diarrhoeal drug events (nausea, heartburn, vomiting). Contraindications : expressed kidney and liver failure, has expressed cardiovascular insufficiency (tsirkulyatorny possible collapse). It is not desirable to use urea swelling of the brain associated with acute cerebral circulation violation, as well as following the powerful anti Auxiliary effect may increase vascular brain, which can lead to the re-bleeding or accede to the softening of hemorrhagic brain. Product : intravenous a dry sterile form to 30; 45; 60 and 90 grams in sealed bottles capacity of 250 and 450 ml. Each bottle is attached to a bottle of 10% glucose solution (75; 115; 150 and 225 ml) to obtain ZO% solution of urea. E-dissolving drug is tempor Urea has also keratoliticheskim action. The Central Research Institute of dermatology and venereology proposed tarpaulin "Ureaplast" (20 g of urea, water 10 g, 5 g beeswax, lanolin 20 g, 45 g lead tarpaulin) and ointment (30% urea) for use as a means keratoliticheskih the treatment onihomikozov. Over the forefront issued keratoliticheskie creams containing 10% urea (Ce ratolan, Sa rbaderm etc.), used to treat ihtioza, ihtiozooformnyh dermatitis, hyperkeratosis. A solution of urea (10%) designated as irrigation, washing, moist dressing to treat wounds festering. Applied also 25% emulsion. There has been accelerated cleansing wounds from necrotic masses, as well as accelerated healing.
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