TUBOKURARIN- CHLORIDE (Tubocurarini chloridum) *. d Tubokurarina chloride.

     Synonyms: Amelizol, Curadetensin, Curarin, Delacurarine, Myostatine, Myricin, Tubadil, Tubaril, Tubarine, Tubocuran, Kurarin- ASTA, Intoksotrin and others.

     The white crystalline powder. Easy soluble in water. d Tubokurarin- chloride is derived bisbenziltetragidroizohinolina. For a long time it was regarded as bischetvertichnoe ammonievoe authority to optical distance between onievymi Group (Quaternary nitrogen atoms) 1 5 nm, the structure shown in the top formula.

     However, in 1970 published the results of chemical and spectroscopic studies showed that one atom of nitrogen molecules d tubokurarina is not quaternary and tertiary. Thus, d tubokurarin should not be regarded as bischetvertichnoe but monochetvertichnoe connection. d Tubakurarin blocks of mostly n-holinoreaktivnye skeletal musculature, to a lesser extent, affects the nervous holinoretseptory vegetative nodes. In high doses, the drug also blocks holinoretseptory vegetative nervous knots, hromaffinnoy tissue ? and karotidnyh klubochkov.

     Small doses of d-tubokurarina can cause temporary relaxation skeletal musculature (relaxation).

     This muscles relax in the following order: muscle fingers hand-eye-foot-neck-back, then intercostals muscle and diaphragm.

     When receiving low doses of stopping breathing may not happen (if not blocked the transfer to the nervous intercostal muscles and diaphragm), but with increased doses are stopped breathing; If it is an artificial lung ventilation, the effect of d-tubokurarina gradually being restored and natural breathing.

     This restoration muscle function occurs in the sequence back to relax. With adequate artificial lung ventilation d tubokurarin no violations of basic bodily functions.

     At the cardiovascular system d tubokurarin expressed direct influence is not, but at the ganglioblokiruyuschim actions may cause lowering blood pressure (usually at 15 - 20 mm Art. Art.) . At TSNS d tubokurarin in normal doses does not have a significant impact. Please note that d tubokurarin to histamine release from the tissue and can sometimes cause bronchial spasm myshsch. d Tubokurarin used mainly as Surgery miorelaksanta causing Muscle relaxation during the operation.

     In traumatic times are d tubokurarinom to relax the muscles in repozitsii otlomkov, lumbar complex vyvihov etc.

     For treatment spasticheskih anesthetic and long muscles of d tubokurarin use is not primarily because of the short caused by the impact and complexity of (the need for artificial lung ventilation.

     Enter d tubokurarin in veins. Effects of the drug develops gradually, usually begins in muscle relaxation 1 - 1, 5 min, and a maximum of comes through 3 to 4 minutes.

     The average dose for an adult is 15 to 25 mg, with the relaxation lasts 20 to 25 minutes. But tubokurarina dose d, as well as other muscle depend on the applied anaesthesia. In general anesthesia combined with the use of nitrous oxide d tubokurarina intravenous dose of 0.4 - 0.5 mg / kg is complete muscle relaxation and simple prodolzhitelynstyu 20-25 min. Fair relax the abdominal muscles and limbs continue to press for 20 - 30 minutes.

     If you want a longer effect, impose d tubokurarin again, and in the ability to follow a cumulative dose should be 1 / 2 - 5 times smaller earlier. Usually operations, the ongoing 2 - 2, 5 h, spent 40-45 mg drug.

     When air anaesthesia initial dose of d-tubakurarina 0.25 0.4 mg / kg.

     Please note that the d-tubokurarina slightly increased if it is applied after ditilina.

     Enter tubokurarin d after transfer to the patient artificial lung ventilation.

     D tubokurarina antagonists are Neostigmine and Galantamine that normally enter with atropine (see). Tubokurarin contraindications for infants. With careful use of old age and severe violations of liver and kidney function.

     Form of: 1% solution in the ampoule and 1, 5 mL (15 mg in 1, 5 ml).

     Storage: List A.

     Plants, which are tubokurarin d, in our country grow. The product is made overseas.

Materials allowed to copy only with the active hyperlink to the handbook of medicines