TRIPSIN (Trypsinum).

     Endogenous proteolytic enzyme, razryvayushy Research in protein molecules. Silicon also products of high protein, polypeptide type peptones, and some nizkomolekulyarnye molecules that contain certain amino acids (Arginine, lysine).

     Trypsin is a protein with a relative molecular mass 21000. Formed in mammalian pancreas gland, which is contained in an inactive form tripsinogena; The latest move in a trypsin under the influence of another enzyme-enterokinazy, and the impact of the obrazovavshegosya trypsin.

     For use in medical practice trypsin from the pancreas of cattle.

     The main medicinal product is crystalline trypsin (T rypsinum with rystallisatum). This product allowed for the local as well as for parenteral use. Trypsin amorphous and himopsin (mixture with trypsin himotripsinom) allowed only for local use.

     Trypsin crystalline powder-white or white with a slightly yellowish tinge of color, odourless, or porous mass (after drying). Easy soluble in water and isotonic sodium chloride solution; PH 0.2% aqueous solution of 3 - 0 5 5. Solutions easily destroyed in the neutral and alkaline environment.

     Application trypsin medical practice based on his ability to split the local impact nekrotizirovannye tissue and fibrinoznye education dilute viscous secrets ekssudaty, blood clotting. The enzyme is active at pH 5, 0, 8, O with optimum activity at pH 7, 0. Relative to healthy tissue enzyme is not active and safe in the presence of trypsin inhibitors (specific and unspecific).

     Apply support as a means to facilitate the removal of viscous secrets and ekssudatov in inflammatory airways disease (traheity, Bronchitis, bronhoektaticheskaya disease, pneumonia, following an atelectasis light, etc.). In these cases, the drug is used for inhalation (in a spray) and intramuscularly. Trypsin is liquefaction sputum and facilitate its selection. When glue chest and empieme aswellaspleuralplaques trypsin can be entered vnutriplevralno for dilution exudation, come and facilitate their evacuation. When tuberculosis empieme should be careful, given that exudation resorption may, in some cases, contribute to the development bronhoplevralnoy fistula.

     In connection with the anti-trypsin also applied to the crystal for intramuscular injection with physiotherapists, vospalitelno- Dystrophic forms dentist, osteomielite, nasal, media and other inflammatory diseases.

     Admission drug leads to a decrease swelling and should be treated as one for the integrated treatment of these diseases. If physiotherapists and flebotrombozah trypsin not replace antikoagulyantov. In paradentosis intramuscular injection recommended podnadkostnichnym combined with a trypsin solution in parodontium.

     In irite, iridotsiklite, hypertension in front of the camera eye infections okologlaznyh tissue after injuries and operations using local and intramuscularly in the form of eye drops and vannochek.

     For the treatment of burns, bedsores, festering wounds using trypsin local (reading and applications see Himopsin).

     Trypsin crystalline impose intramuscularly for 0,005 adults - 0.01 g (5 - 10 mg), 1 to 2 times a day for children to 0.0025 g (2, 5 mg) 1 every day. To dissolve immediately before injection of 0,005 grams (5 mg) in the crystalline trypsin 1 - 2 mL of sterile isotonic sodium chloride solution, or 0.5 to 2% solution of Novocaine. Solution enter deeply into the upper outer Quadrant rump muscle. In the course of 6-15 injection.

     Apply also trypsin by electrophoresis. 10 mg trypsin (1 procedure) dissolve in the 15 - 20 ml of distilled water. Enter product with a negative pole.

     To dissolve inhalations 5 - 10 mg-in-2 - 3 ml isotonic sodium chloride solution and used as a spray through the pump or enter through bronhoskop or endotrahealny probe. Number inhalations depends on the current disease and the effectiveness of therapy. After inhalation poloskayut warm water and wash his mouth nose. In inhalation can be added to the solution bronhorasshiryayuschie substances and antibiotics.

     Intraplevralno enter one time a day, 10 to 20 mg product dissolved in 20 ml - 50 isotonic sodium chloride solution.

     In practice, apply Eye 0.2% solution for vannochek and 0.25-1% solution in the form of eye drops (3 to 4 times a day for 1 - 2 - 3 days). When annoyed reduce the concentration of the solution or stop drug use.

     In appointing trypsin should be possible complications. For parenteral use only a crystalline trypsin. After introducing vnutrimyshechnogo may arise, and the pain of making blood at the injection site, and after vnutrimyshechnogo and vnutriplevralnogo of-allergic reactions associated mainly with vacuum products proteolysis nekrotizirovannyh tissue. May observed temperature increase and tachycardia. To prevent and remove allergic phenomena protivogistaminnye use drugs. In inhalation trypsin can be an irritant mucous membranes and upper respiratory tract ohriplost vote. After inhalations should be possible to fully remove the sputum (asthmatics or optional).

     Trypsin contraindications to cardiac decompensation of emphysema to lung respiratory distress, dekompensirovannyh forms of pulmonary tuberculosis, malnutrition and liver cancer, infectious hepatitis, liver defeat, pancreatitis, haemorrhagic diathesis. We should not impose drug hotbeds of inflammation and bleeding in the cavity. We can not impose trypsin intravenously, and the cause (and other proteolytic enzymes) izyazvlennye on the surface of malignant tumors in order to avoid the spread of malignant process.

     Form release: in the ampoule or hermetically ukuporennyh vials containing at 0,005 and 0.01 g (1 and 10 mg) crystalline trypsin.

     Storage: a dry, sheltered from the world scene with a temperature of not more than + 10 'S.

     R p. : Trypsini crystallisati 0,005

     D.t.d. N. in ampull 10.

     S. For intramuscular injection. Dissolve 1 to 2 ml of sterile isotonic sodium chloride solution

     Rp. : Trypsini crystallisati 0.01

     D.t.d. N. in ampull 6.

     S. For inhalations. Dissolve 2 -3 ml isotonic sodium chloride solution

     A special dosage forms crystalline trypsin treatment to treat his wounds (Daltseks- trypsin and trypsin Pax). Trypsin immobilizovan specialty polymer base (line). Issued otrezy line size of 10 x 7, 5 to 30 cm x 20 cm in polyethylene bags.

     Packs (after treatment) to treat wounds, zakrelyayut bandage, on the wounds left by 24-72 h.

     Before applying to the wound ml distilled water line or furatsilina solution.

Materials allowed to copy only with the active hyperlink to the handbook of medicines