Triptorelin (triptorelin)

TRIPTORELIN (Triptorelin).
     Synonyms: Dekapeptil, Diferelin, Decapeptyl, Diphereline.
     Synthetic analogue gonadotropin- rilizing- factor.
     It features of the natural hormone more slowly biotransformation and slow disbursement of the body.
     Issued in the form of acetate (C64H82N18O13 · C2H4O2).
     As of close to buserelinu (see).
     In vnutrimyshechnom and a subcutaneous bioavailability of about 39% and 69%, T? - 7.6 hours
     Apply with endometriosis, uterine miome, advanced ovarian carcinoma, gormonozavisimom cancer prostate gland, in the extracorporeal procedures.
     Assign subcutaneously or intramuscularly.
     Subcutaneously (mainly in the treatment of infertility) impose on one 0.5 mg once a day for 7 days, then to 0.1 mg per day. With deposit forms (Diferelin- depot) impose on 3.75 mg intramuscularly 1 every 4 weeks for up to 6 months.
     Possible side effects: weakening drive, Gynecomastia, reduced bone mineralization, breaches of sleep, mood changes, depression, a violation of view, joints, increased blood pressure, local allergic reactions, etc.
     The product contraindications to polikistoze ovaries, gormononezavisimom prostate gland cancer, osteoporosis, pregnancy and breast feeding.
     Method of issuance: 0.01% and 0.05% solutions for injection syringe in one ampoule and 1 ml; Powder for suspensions for subcutaneous introduction in vials of 0.1 mg and prolonged release suspension for a vnutrimyshechnogo in vials and microcapsules ( disposable syringes) to 3.75 mg together with the solvent.

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