TRIMETIN (Trimethinum). 3, 5, 5-Trimetiloksazolidindion-2, 4

     Synonyms: Absentol, Edion, Epidione, Petidion, Ptimal, Trepal, Tridione, Trimedal, Trimethadionum, Troxidon.

     The white crystalline powder with weak holodyaschim peculiar smell and bitter taste. Soluble in water, easily soluble in alcohol,

     Trimethadione protivosudorozhnym a tool used mainly in small forms of epilepsy, and mental and sosudisto vegetative equivalents.

     The product is rapidly absorbed. Peak concentrations in the blood plasma through a 1 / 2 to 2 h after administration. Slowly allocated from the body. Period polususchestvovaniya in blood plasma was 12-24 h.

     Product (demetiliruetsya) in the liver to form the active metabolite (demetadion), slowly extra kidneys. In a lengthy application product can accumulate in the body.

     Assign Trimethadione inside (during or after the meal): Adults usually 0.2 - 0.3 g 2 - 3 times a day, the children of 0.05-0.1 - 0.15 - 0.2 g 2 - 3 every day. Treatment rates for a three-five months. In appointing carry Phenobarbital.

     Higher doses for adults: single 0.4 g daily 1, 2 d.

     Trimethadione, like several other drugs protivoepilepticheskih has analgesic effect in troynichnogo nerve neuralgia, but is slower than Carbamazepine (see). Recommended award Trimethadione with troynichnogo neuralgia nerve in the following doses: in the first week of 0.2 g 4 times a day, the second-to 0.2 g three times a day, in the third - to 0.2 g 2 times a day in the fourth week, 0.2 g 1 every day. This dose is usually designated in the future as supporting.

     When treating trimetinom might be side effects: light, blindness, skin rashes, dermatitis eksfoliativny, change the formula blood (neutropenia, agranulotsitoz, disease, eosinophilia, monotsitoz). In the treatment, at least every 10 days should be a study of blood.

     Application trimetina can provoke the development of large attacks of epilepsy, and are encouraged to nominate a protivoepilepticheskie Phenobarbital or other drugs.

     There is evidence of potential teratogenicity of the drug.

     With regard to side effects and the emergence of new and more effective drugs Trimethadione currently has limited application.

     Trimethadione contraindications for violations of liver and kidney, blood diseases and visual nerve.

     Form release: powder.

     Storage: List B. The well ukuporennoy packaging.

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