TRIMEKAIN (Trimecainum). a-Dietilamino-2, 4, 6-trimetilatsetanilida hydrochloride.

     Synonyms: Mesdicain, Mesidicaine, Mesocain, Trimecaini hydrochloridum.

     White or white with a yellowish sheen weak crystalline powder. Very easily soluble in water, easy-to alcohol. Solutions (pH 4, 5, 5.2) are preparing for isotonic sodium chloride solution, sterilize with + 100 C for 30 min.

     According to the chemical structure and pharmacological properties trimekain close to lidokainu. The chemically different from lidokaina a methyl group of four fenilnogo kernel.

     Trimekain an active mestnoanesteziruyuschim funds.

     It was coming fast, deep, long infiltratsionnuyu, conductors, epidural and spinal anesteznyu; In higher concentrations (2 - 5%) and surface anesthesia.

     Trimekain operates more heavily and more duration than Novocaine. Relatively little toxic, is not annoying actions.

     For infiltratsionnoy trimekain anesthesia used in a 0.125% solution (up to 1500 ml), 0.25% (800 ml), or 0.5% solution (400 ml). The total dose of the drug for adults should not exceed 2 years

     For conductors anesthesia using 1% solution (100 mL) and 2% solution (20 ml); For epidural - 1%; 1, 5% or 2% solution (sometimes mixed with autokrovyu); Add Adrenaline (0, 1% solution adrenaline hydrochloride for 5 to 8 drops to 20-25 ml trimekaina). Enter carefully-fraktsionno: 1% Solution in the first dose of 5 mL, followed by 10 ml (total of 50 mL); Solution 2% - to 20-25 ml.

     For spinal anesthesia using 5% solution (2 to 3 ml), a surface-to 2 - 5% solutions: in ophthalmic practice, 4 to 8 drops in Otorhinolaryngology-2 - 8 drops (with the addition of 0.1% epinephrine solution hydrochloride: a drop of 1 per 2 ml trimekaina).

     Trimekain appointed as antiaritmicheskogo funds. Mechanism of the evidence and to use the same as for lidokaina. But trimekain less efficient than lots.

     Ways to implement the dose trimekaina the application as a means antiaritmicheskogo about the same as for lidokaina: usually begin entering struyno intravenously 80-120 mg (a 2% solution), then kapelno (a day) at a speed of 2 mg per minute (0.1 - 0.2% solution in isotonic sodium chloride solution).

     Trimekain generally well tolerated by, and overdose possible side effects, like Novocaine.

     Method of issuance: powder; 0.25% solution in 10 ml ampoule; 0.5% and 1% solutions in the ampoule of 2, 5 and 10 ml; Solution 2% to 1; 2; 5 and 10 ml and 5% solutions on 1 and 2 ml.

     Storage: List B.

     Trimekain part of the aerosol products "Tsimezol (see Tsiminal).

Materials allowed to copy only with the active hyperlink to the handbook of medicines