TRIFTAZIN (Triftazinum). Triftormetil-10- 2-[3-(1-metilpiperazinil-4) - propyl] - fenotiazina digidrohlorid.

     Synonyms: Stelazin, Trifluoperazin, Aquil, Calmazine, Clinazine, Equazine, Eskazine, Fluazine, Fluperin, Jatroneural, Modalina, Parstelin, Stelazine, Terfluzine, Trifluoperazini hydrochloridum, Trifluoperazine hydrochloride, Trifluoroperazine, Trifluperazine, Triflurin, Triperazine, Vespezine, Yatroneural and others.

     White or slightly greenish-yellow crystalline powder. Easy soluble in water, soluble in alcohol. In light dark.

     On chemical structure differs from triftazin aminazina that instead of chlorine atom in the position fenotiazinovogo kernel contains two group C F W, and the side chain-kernel piperazine, replacement with nitrogen atom of four CH 3 groups (like meterazina).

     Triftazin is one of the most active antipsychotic drugs. Adjunct effect combined it with a mild stimulant effect (energeziruyuschim). In gallyutsinatornyh and gallyutsinatorno- delusional state is sedative effect. The product provides strong protivorvotny effect.

     Unlike aminazina triftazin adrenolitichesky has little effect. Less potentsiruet of offering funds; No protivogistaminnoy, skin and protivosudorozhnoy activity. Provides strong katalepticheskoe effect.

     Apply in psychiatric practice for the treatment of schizophrenia, especially paranoid, nuclear and low, and other mental illnesses, with nothing of ongoing STDs and hallucinations, in involyutsionnyh psychosis, neuroses and other nervous diseases.

     Triftazin has more pronounced effects on the productive psihoticheskuyu symptoms (hallucinations, crazy) than aminazin. Triftazina feature is the absence of constraint, general weakness, oglushennosti if it is applied; Conversely, patients often become more lively, are beginning to show interest in the environment, it is easier to engage in employment processes. In the early days of treatment may be a confusion.

     Assign triftazin inside (after eating) and intramuscularly. Single dose of admission into early treatment is normally 0,005 grams (5 mg). In the future, gradually increasing the dose at 0,005 g for admission to the total daily dose of 0,03 - 0,08 g (in some cases up to 0.1 - 0.12 g / day); The daily dose divided into 2 - 4 admission. Upon reaching the optimal therapeutic effect doses remain within 1 to 3 months, then reduce to 0.02 - 0,005 grams per day. These doses designated in the future as support.

     Intramuscularly triftazin imposed in cases requiring a rapid effect. Initial dose is 0,001 - 0,002 grams (1 to 2 mg). Repeat injections through 4 to 6 hours Daily dose usually under 0,006 grams (6 mg), in rare cases, up to 0.01 g (10 mg).

     For patients alcoholism triftazin used for the treatment of acute and chronic gallyutsinatornyh and raving Psychosis, kupirovaniya psychomotor stimulation. In sharp psihoticheskih able to begin treatment with intramuscular injection, turning inwards to pick up after the withdrawal of acute psychosis phenomena. Assign also triftazin to treat nevrozo- and psihopatopodobnyh violations in patients alcoholism, when apatoabulicheskih state, and when combined with drugs - when depressivnobredovyh and anxiety gallyutsinatornyh states.

     Triftazinom treatment can be combined with the appointment of other brain, tranquilizers, antidepressants.

     As a means of applying protivorvotnoe triftazin with vomiting different etiology of 0,001 - 0,004 grams (1 to 4 mg) a day.

     When treating triftazinom relatively often extrapyramidal disorders: dyskinesia, akinetorigidnye phenomenon Akathisia, tremor, vegetative violations. As proofreaders appoint ANTIPARKINSONISM funds (Trihexyphenidyl, tropatsin etc.). Dyskinesia (paroksizmalno emerging convulsions neck muscles, the bottom oral language, okulogirnye crises, etc.) kupiruyut kofeinbenzoatom sodium (2 mL of 20% solution under the skin) or aminazinom 1 - 2 mL of 2, 5% solution intramuscularly).

     Triftazin less is a violation of the liver and agranulotsitoz than aminazin; Rarely are allergic skin reaction.

     The product contraindications in acute inflammatory liver diseases, heart disease with the conductivity and being decompensation with severe blood diseases, severe liver and kidney diseases, pregnancy.

     Method of production: tablets covered with yellow skin, to 0,001; 0.005 and 0.01 grams in a package of 50 pieces; 0.2% solution of 1 ml ampoule in the package of 10 vials.

     Storage: List B. The well ukuporennoy packaging keeps out of light and moisture. Pill-in a dry, sheltered from the world scene.

     R p. : Tab. Triftazini 0,005 N. 50

     D.S. At one tablet two times a day

     Rp. : Sol. Triftazini 1 ml 0.2%

     D.t.d. N. in ampull 6.

     S. On 1 - 2 ml intramuscularly

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