TRANDOLAPRIL (Trandolapril).

     Ethyl ether [1-karboksi-3- fenilpropil] alanil] - geksagidro-2- indolinkarbonovoy acid.

     Synonym: Gopten, Gopten.

     Colourless crystalline powder. Soluble in methanol, chloroform and dichloromethane.

     Alaninsoderzhaschy inhibitor APF long-term (up to 48 h).

     In the body product (hydrolyses) with the formation of acid-trandolaprilata.

     When you receive inside quickly and completely absorbed, bioavailability of 10% (from trandolaprilata - 40-60%), C max-1 h (4-10 from trandolaprilata-p), T? - 16-24 h; output mainly from faeces.

     Apply with arterial hypertension and congestive heart failure and heart attacks after myocardial dysfunction of the left ventricle.

     Assign inside. Initial dose of 0.0005 g (0.5 mg) one time a day, then it increases with an interval of 2-4 weeks prior to 0,001-0,002 grams (1-2 mg); The maximum dose of 0,004 grams ( 4 mg) per day.

     Side effects and contraindications essentially the same as that of the amlodipine and Captopril.

     Form release: capsules of 0.0005 and 0.002 g (0.5 mg and 2) (N 28).

     Storage: List B.

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