TOPOTEKAN (Topotecan).

     (S) -10-[(Dimetilamino) - ethyl] -4 - ethyl-4, 9-dihydroxy-1 H Pirano [3? , 4? : 6,7] indolizino [1,2-b] Quinoline-3 14 (4 H 12 N) - glows hydrochloride.

     Synonym : Gikamtin, Hycamtin.

     Semi derived alkaloid kamptotetsina, extracted from the stems of shrubs Campotheca acuminata.

     The crystalline powder. Mg in the water.

     On mechanism of close to irinotekanu.

     Applied with ovarian cancer, lung and chronic leukemia mielomonotsitarnom.

     Enter intravenous drip (within 30 min) in the dose of 1.5 mg / m 2 / day for 5 days with an interval of 16 days (at least four courses).

     Possible side effects : neutropenia, radiation, thrombocytopenia, anemia, diarrhoeal phenomenon parestezii, arthralgia, allergic reactions.

     Contraindications : mielosupressiya, pregnancy, breast-feeding, childhood.

     Product : dried powder for injection solutions in vials of 0,004 grams (4 mg).

     Storage : List B.

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