TIZANIDIN (Tizanidine). Hlor-4- 5 - (2-amino imidazolin-2- mud), 2, 1, 3-benzotiadiazol.

     Available as hydrochloride.

     Synonyms : Sirdalud, Sirdalud (SANDOZ ").

     The white or slightly yellow melkokristallichesky powder.

     Central to the muscle. Suppress polisinapticheskie spinal reflexes and has antispasticheskoe of the increased muscle tone, relieve cramps and convulsions klonicheskie.

     On Tizanidine pharmacologically similar to midokalmom and baklofenom, but differs from them on the operation. Thus, increasing activity Baclofen GAMKergicheskoy mediator braking system, the impact tizanidina due to the lower release of interneyronov incident mediator amino acids (see Glutamic acid).

     Tizanidine quickly and almost completely absorbed by ingestion. The maximum concentration in plasma is 1 to 2 hours In unaltered drug and metabolites are primarily in the urine.

     Applied Tizanidine with painful muscle cramps associated with static and functional damage to the spine (cervical and lumbar syndromes), and after surgery (about slipped disc or hip arthritis), and Spasticity due with multiple sclerosis, mielopatiey chronic, degenerative diseases spinal cord, stroke and convulsions central origin.

     Is Tizanidine inwards in the form of tablets. To remove the pain of muscle spasm designate an adult to 2 to 4 mg (0,002 - 0,004 grams), 3 times a day (regardless of meal times). If the effect is not enough, take an additional 2 to 4 mg per night. In Spasticity caused neurological disturbances, appointed in tailor-made doses, starting with a daily dose of 6 mg (3 admission); Gradually increase the daily dose (intermittently 4 to 7 days) at 2 to 4 mg. The optimal daily intake is usually 12 to 14 mg (reception 3-4). The daily dose should not exceed 36 mg.

     Tizanidine is usually well but could experience mood, a sense of fatigue, dizziness, dry mouth, nausea, a slight drop in blood pressure. At higher doses may muscle weakness, insomnia, hypotension, aetiology; In some cases, a temporary increase in transaminaz in blood serum.

     The drug should not be taken in pregnancy and breastfeeding. There is enough experience with his children.

     In violation of liver and kidney dose reduced.

     In connection with possible disturbances and muscle weakness should be careful in appointing a drug persons whose work requires quick mental and physical reaction (operators, drivers of vehicles, etc.).

     Please note that the simultaneous application tizanidina and antigipertenzivnyh drugs, including diuretics, can cause increased hypotension and bradycardia.

     Alcohol and sedatives may increase the sedative effect tizanidina.

     Product : pill (risk), containing 0,002; 0,004 or 0,006 grams (2; 4, or 6 mg) tizanidina.

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