Tienam (tienam)


TIENAM (Tienam) (name drug companies "MERCK & CO. , INC. "Rahway N. J., U.S.A.).
     Tienam is a combination of sodium salts and antibiotics imipinema digidropeptidazy kidney enzyme inhibitor (tsilastatina) in the ratio of 1:1.
     Cilastatin (S ilastatin). [6 Karboksi-6- (2, 2-dimetiltsiklopropankarboksamido) -5 - hexen] -L- cysteic.
     Tienam used in a variety of infections caused by susceptible to imipenem infection, infection in the abdominal cavity, lower respiratory tract infections, septicemia, urinary tract infections, skin infections, soft tissue, bones and joints. When meningitis tienam use is not recommended.
     Enter intravenously. Normal daily intake for adults 1 to 2 g (April 3 admission). When heavy dose of infection for adults can be increased to 4 g / day to further its reduction. Enter a day more than 4 grams is not recommended. If the kidney function, medication use, in small doses, depending on the severity of the defeat of 0,5 - 0,25 g in 6 - 8 12 hours
     For intravenous tienam produced in bottles with a capacity of 60 ml, containing 0.25 g (250 mg) and imipenem tsilastatina 0.25 g, and 120 ml bottles containing 0.5 grams and 0.5 grams imipenem tsilastatina. Dissolve in a buffer solution of sodium gidrokarbonata. Dose 0.25 g preparation plants in 50 mL solvent, a dose of 0.5 grams per 100 mL solvent. Enter in the vein slowly for 20 to 30 minutes. When dose 1 g, a solution to over 40-60 minutes.
     Children weighing more than 40 kg to enter tienam in the same dose as adults, and weighing less than 40 kilograms at the rate of 15 mg / kg intermittently in 6 hours
     The total daily dose should not exceed 2 grams Children under the age of 3 months tienam not appointed.
     For drip introductions to throw solution tienama in isotonic sodium chloride solution, or 5% glucose solution.
     If necessary, introduce a solution tienama intramuscularly. Usual adult dose of 0.5 - 0.75 g every 12 hours The daily dose should not exceed 1 5 Enter city deep in the muscles. For intramuscular injection drug produced in vials containing 0.5 or 0.75 grams imipenem and the same number tsilastatina. Applied solvent (2 to 3 ml), which added to lidocaine solution. When breeding formed suspension white or slightly yellow.
     Possible side effects are basically the same as when applying liquid.
     Storage : powder in bottles at room temperature. Solutions are presented for isotonic sodium chloride solution, can be stored at room temperature (25 C) for 10 h, in the refrigerator (+ 4 'C) - to 48 h. Tienama Solutions, which is 5% glucose solution, in a 4 or 24 h. Finished suspension should be used within one hour.
     Solutions tienama solutions should not be confused with other antibiotics.

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