TROMBIN (Thrombinum).

     Thrombin is a natural component of the blood coagulation system, formed in the body from protrombina in fermentative activated last tromboplastinom.

     For use in medical practice from the plasma of blood donors.

     The white amorphous powder odourless. Soluble in 0.9% sodium chloride solution, the solution pH 6, 2 - 7, 2.

     Drug activity expressed in terms of activity (EA). For one unit of thrombin activity are so many drug activity, which could collapse at a temperature of 37 + 'from 1 mL of fresh plasma for 30 or 1 ml of 0.1% solution of purified fibrinogena 15.

     Released in glass vials or ampoule with a capacity of 10 ml, containing at least 125 units of activity. Number of drug activity indicate vial or vials.

     Solution thrombin apply only to stop local bleeding from the small capillaries and parenchymatous organs (with skull-brain operations, operations on the liver, kidneys and other parenchymatous organs, krovotecheniyah of bone cavities, gum, etc., especially when Verlgofa disease, and aplastic gipoplasticheskoy anemia). In krovotecheniyah major vascular hemostasis not apply. Introduction to the veins and muscles are not allowed. Introduction to the blood vessels can cause widespread coronary deaths.

     Before use, in keeping with the rules of reimbursement, reveal vials with thrombin and sterile syringe giving it Sterile isotonic sodium chloride solution room temperature. The number of solution depends on the number of vials of thrombin and indicated on the label. Solution thrombin permeate gemostaticheskuyu sterile sponge or gemostaticheskuyu collagen sponge (see) a Sterile gauze bandage Tampon to impose on the bleeding wounds. Tampon gauze bandage removed immediately stop bleeding (if the wound closed closed) or regular transparent (if treatment to open).

     Remove from Tampon wounds carefully to avoid damage resulting embolism. Gemostaticheskuyu sponge, impregnated thrombin, can be left in the wounds, as it subsequently resolved.

     Storage: in a dry place with a temperature of up to + 2 + 10 'C.

Materials allowed to copy only with the active hyperlink to the handbook of medicines