TIOPENTAL SODIUM (Thiopentalum natrium).

     The mixture of sodium salt 5 - (1-methylbutyl) -5 - ethyl tio6 arbiturovoy acid with anhydrous sodium carbonate.

     Synonyms : Farmotal, Intraval, Leopental, Nesdonal, Penthiobarbital, sodium Pentothal, Pharmotal, Thiomebumal sodium, Thionembutal, Thiopental sodium, Thiopentalum narticum cum Natrii carbonate, with Sodium Thiopental sodium carbonate, Thiopenten, Thiopentobarbital, Thiopentone, Thiopentone sodium, Thiotal, Thiotal natrium , Tionan, Tiopanal, Trapanal and others.

     Dry powder or porous mass of yellow or yellowish green color with svoebraznym smell. Gigroskopichen. The easily soluble in water. An aqueous solution is alkaline reaction (pH of about 10.0).

     Solutions tiopental- nestoyki sodium, so they were prepared just before use in aseptichesnih conditions.

     Tiopental- sodium, and geksenal has sleeping pills and narcotic effects. On pharmacologically similar to geksenalu, but a few more. It is the strongest muscle relaxation than geksenal.

     Compared with geksenalom tiopental- sodium (like other tiobarbituraty) to have a greater influence on the incident wandering nerves and can cause laringospazm, copious mucus secretion and other signs vagotonii. Therefore tomography tiopental- sodium less suitable than geksenal (GI Lukomsky). Tiopental- sodium fast breaks (mainly in the liver) and out of the body. After a single dose of anaesthesia continued 20 to 25 minutes.

     Tiopental- sodium applied as a tool for self narcosis mainly short surgical intervention, as well as induction and bazinogo narcosis and then use other means to narcosis. The drug can be used in combination with the muscular Ward provided a tank (IVL).

     Tiopental- sodium injected, and rectally (mostly children).

     Enter tiopental- sodium in the veins to be slow (to avoid collapse!) .

     For narcosis used in adults 2-2.5% solution, but in children, weakened sick and the elderly-1%. Solutions are neposredstenno before consumption of sterile water for injection. Solutions must be absolutely transparent.

     To prevent complications associated with increased tone wandering nerve (laringospazm, muscle spasm, bronchi, and increased salivatsii etc.), the patient before entering narcosis metacin or atropine.

     Using tiopental- sodium for induction narcosis adults impose 20 - 30 ml of 2% solution. The same number are in the application of a tiopental- sodium for small operations : first 1 - 2 ml, and after 30 - to-40 remaining.

     As for the base narcosis children tiopental- sodium shown mainly elevated nervous excitability. Applied rectally as 5% of warm (32-35 + C) solution at the rate of 0.04 g (up to 3 years) and 0.05 g (3 - 7 years) at one year of life.

     The highest single dose of adult non-1 yr

     Tiopental- natrny is not suitable for organic diseases of liver, kidney, diabetes, severe exhaustion, shock, collapse, bronchial asthma, inflammatory diseases direction, frantic sostoniyah, with a sharp expressed violations bloodstream. A provision in the history of a patient or his relatives had an acute porphyria is an absolute contraindications to the use tiopental- sodium.

     Antogonistom tiopental- sodium is Bemegride.

     Tiopental- sodium should not be confused with ditilinom, pentaminom, aminazinom, diprazinom (rolls sludge).

     Product : tiopental- sodium dried (Thiopentalum-n a trium ly on philisatum) of 0.5 and 1 g in 20 ml vials of capacity, sealed rubber congestion, obzhatymi aluminum caps.

     Storage : List B. In a cool, dry, the dark spot.

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