TIOKTOVAYA ACID (Thioctic acid)

     Chemical name : 1,2-Ditiolan-3- pentanovaya acid (in the form amide or sodium salt)

     Description : Light yellow crystalline powder bitter taste. Nerastvorim water (sodium salt rastvorima) and is soluble in alcohol.

     Pharmacology : The drugs act-gepatoprotektivnoe, dezintoksikatsionnoe, gipoholesterinemicheskoe, lipid and antioxidant.

Is kofermentom oxidative decarboxylation dofamine acid and alpha ketokislot, normalizes the energy, carbohydrate and lipid exchanges, regulates the metabolism of cholesterol. Improves liver function, reduces damaging influence of endogenous and exogenous toxins.

Once inside quickly and adequately absorbed, Cmax achieved after 50 minutes. Bioavailability is about 30% (by presistemnoy biotransformation). In the liver oxidizes and konyugiruet. Kidney excreted in the form of metabolites (80-90%) with T1 / 2 20-50 minutes. Total plasma-Cl 10-15 ml / min.

     Application : Koronarny atherosclerosis (prevention and treatment), liver disease (disease Botkina mild and severe, liver cancer), polineyropatiya (diabetic, alcoholic), heavy metal poisoning salt, etc. intoxication.

     Contraindications : Giperchuvstvitelnost, pregnancy, breast-feeding.

     Side Effects : Violation of the metabolism of glucose (hypoglycemia), allergic reactions (including anaphylactic shock); With the rapid on / in a short-delay or difficulty in breathing, increased vnutricherepnogo pressure, convulsions, diplopia, point bleeding in the skin and mucous, mitochondrial dysfunction.

     Networking : gipoglikemiziruyuschih enhance the effects of oral drugs and insulin.

Ringera is not compatible with solutions and glucose compounds (including their solutions), responsive to disulfidnymi and association groups or alcohol.

     Overdosing : Symptoms : headaches, nausea, vomiting.

Treatment : maintaining vital functions.

     Dosing and Administration : inside (not liquid, squeezed a small amount of water) to 1 x 300-600 mg / day (morning), for 2-4 weeks or more.

In / in a slow (at speeds of up to 50 mg / min), 300-600 mg of Infusion solution at physiological 1 per day during 2-4 weeks, and then inside of 600 mg per day.

     Precautions : svetochuvstvitelen preparation. Ampoules of the package should be delivered only to use. Solution for Infusion suitable for introduction during the 6 h, if protected from the effects of light.

Materials allowed to copy only with the active hyperlink to the handbook of medicines