TIOATSETAZON (Thioacetazonum).

     Thiosemicarbazide atsetaminobenzaldegida parameters :

     Synonyms : Tibon, Ambathizonum, Amithiozon, Benzothiozone, Conteben, Diazan, Myvizon, Parazone, Tebethion, Thiomicid, Tibion, Tibisan, Tizone, Tubercazon, Tubigal, Vitazone and others.

     Light yellow melkokristallichesky powder, bitter-tasting.

     Almost nerastvorim in water, soluble in alcohol difficult.

     Tioatsetazon has bakteriostaticheskoy activity against M. tuberculosis and leprosy cause. However, the relatively high toxicity limited their use : Designate usually combined with isoniazid, ftivazidom, PASK, streptomycin and other anti-TB drugs to increase therapeutic effect and reducing the possibility of the emergence of resistant forms of M. tuberculosis. Combine with ciprofloxacin is not recommended for the cross-resistant mycobacteria.

     Applied primarily with tuberculosis and answer seroznyh envelopes Normally, skrofuloderme, specific disabilities.

     In tuberculous meningitis is not appointed.

     In some cases, tioatsetazon provides therapeutic effect with leprosy, the most effective in the early stages of the disease.

     The drug taking inside after eating; ?high cup of tea, water, milk.

     Daily intake for adults 0.1 - 0.15 g (0.05 g 2 - 3 times a day) for patients over 60 years of age and weighing less than 50 kg to 0.1 g per day.

     Children appoint 0.0005 - 0.001 g (0.5, 1, 0 mg) for 1 kg of body weight per day (no more than 0.05 grams per day).

     When treating tuberculosis empiem, sometimes using 1% sterile suspended tioatsetazona (in the oil, glycerine, isotonic sodium chloride solution).

     When treating tioatsetazonom possible headache, nausea, dermatitis, declining appetite. In rare cases, high doses developed hypertensive, hepatitis, sometimes radiation, thrombocytopenia, agranulotsitoz, anaemia. There could be hypertensive, tsilindruriya, liver failure.

     Treatment tioatsetazonom be conducted under close medical supervision to the systematic control of the kidneys, liver, state haematopoietic system. When the protein in the urine, expressed allergic reactions, increased anaemia, jaundice, starting with agranulotsitoze and expressed adverse drug events cancelled.

     Contraindications : violations of liver and kidney disease haematopoietic system.

     When treating leprosy should not be combined with tioatsetazon diafenilsulfonom (see).

     Product : pills (light yellow) to 0,025, and 0.05 grams in a package of 100 pieces.

     Storage : List B. In dry, the dark spot.

Materials allowed to copy only with the active hyperlink to the handbook of medicines