TIAMIN (Thiaminum).

     VITAMIN B (W Vitaminum 1).

     Synonyms : Aneurin, Anevryl, Benerva, Beneurin, Berin, Betabion, Betamine, Betaneurin, Betavitan, Betaxin, Bethiamin, Bevimin, Bevital, Bevitine, Crystovibex, Oryzanin, Thiamin, Vitaplex B1, etc.

     In nature, vitamin B 1 in yeast, wheat embryos and skin, Oats, Buckwheat, as well as bread, made from flour milling simple.

     In thin milling of the richest vitamin B 1 part grain to remove the bran, it is in the higher grade of flour and bread intake of vitamin B 1 drastically reduced.

     For medical purposes using synthetic drugs (thiamine thiamine chloride and bromide), the natural vitamin B 1 : 4-methyl-5-b-oksietil-N- (2-methyl Amino methyl pirimidil) - tiazoly bromide (or chloride) gidrobromid (or hydrochloride).

     Thiamine bromide (T hiamini bromidum) - white or white with a slightly yellowish sheen powder. Thiamine chloride (T and mini hi chloridum), a white crystalline powder. Both drugs are weak characteristic smell of yeast. The easily soluble in water. The solutions (pH 2, 7, 3, 6) in sterile 100 'C for 30 min.

     Drugs vitamin B 1 (thiamine bromide and thiamine hydrochloride) used as a special fund for the prevention and treatment of hypo-and vitamin B 1.

     Apart from the preventive and therapeutic actions in a hypo and beri - beri, testimony to the use of vitamin B 1 are neuritis, back, disease, chronic peripheral.

     The positive results observed in the treatment of vitamin B 1 sick stomach ulcers and duodenal ulcers, with atony intestines, and liver diseases. While the positive impact of vitamin B 1 in the attack dystrophy, peripheral vascular spasm (endarteriit etc.).

     In practice DERMA vitamin B 1 used in Medicine nevrogennogo origin itch different etiology, piodermii, eczema, psoriasis.

     An analysis of the mechanism of action of vitamin In one should keep in mind that this and other vitamins are not only specific "antivitaminoznymi" means. Actively influencing different body functions, interfering with the metabolism and nerve-reflexive regulation, they can cause a positive effect in various pathological processes, and therefore should be treated as pharmacotherapy substances in a broad sense.

     Of the pharmacological characteristics of vitamin B 1, is not directly related to their vitamin properties, in particular deserve attention his ability to influence the conduct of proceedings in the nervous synapses. Like other compounds containing quaternary nitrogen atoms, it has ganglioblokiruyuschimi and kurarepodobnymi properties, though expressed in a moderate way. Polarization effects on the processes of neurotransmission synapses, it could weaken kurarepodobnoe of depolyarizuyuschih muscle Ward (ditilina etc.).

     Applied vitamin B 1 inside (after eating) and parenteral.

     Daily demand for vitamin B 1 is an adult about 2 mg; With heavy physical labour needed vitamin few more. DSA doses for children : children aged from 6 months to 1 year, 0.5 mg; 1 to 1, 5 years, 0.8 mg; 1, 5 and 2 years old - 0.9 mg; From 3 to 4 years 1, 1 mg; from 5 to 6 years 1, 2 mg; from 7 to 10 years - 1, 4 mg; from 11 to 13 years - 1, 7 mg; boys 14-17-1, 9 mg ; girls 14 to 17 years - 1, 7 mg.

     In therapeutic uses of thiamine chloride and bromide use of thiamine inside (after eating) and parenteral.

     When administered dose thiamine chloride is for adults 0.01 g (10 mg), 1 - 3 (5) times a day. Children under the age of 3 years appoint 0,005 grams (5 mg) a day; 3 - 8 years - 0,005 g three times a day by day; Over 8 years of 0.01 g 1 - 3 times day. The course of treatment is usually 30 days.

     Thiamine bromide because of its greater relative molecular mass (435, 2) apply to a high dose than thiamine chloride (otn. pier. Mass 337, 27); 0,001 (1 mg) of thiamine chloride with the activity of 0.00129 g (1, 29 mg) of thiamine bromide.

     When violations blowing in the gut and the rapid creation of high concentrations of vitamin B blood type thiamine chloride or bromide parenteral thiamine. Usually impose intramuscularly for 0,025 adults-0.05 g thiamine chloride (1 ml 2, 5% or 5% solution) or 0,03 - 0,06 g thiamine bromide (1 ml of 3% or 6% solution) 1 every day every day; introducing children to 0.0125 g (0.5 ml, 2, 5% solution) thiamine chloride or 0,015 grams (0.5 ml of 3% solution) thiamine bromide. The course of treatment 10-30 injection.

     Vitamin B 1 is usually well. Intradermal injections (sometimes intramuscular) painful at the low pH solutions. In some cases, after the vitamin injection (less after receiving inside) possible allergic reaction (swelling Kvinke, urticaria, skin itch). With the non-allergic complications can be more severe; It may cause anaphylactic shock.

     Allergic reactions and insights are being developed for people prone to allergies, women in menopause and predklimaktericheskom times, the alcohol.

     Parenteral thiamine Start introduction to the low dose (0.5 ml more than 5% or 6% solution), and only with good endurance to move to higher doses.

     Thiamin is contraindicated for people with allergic diseases and drug lactose in history.

     Not recommended simultaneous injection of vitamin B 1 introduction of pyridoxine (vitamin B 6) and tsianokobalaminom (vitamin 12). Tsianokobalamin increases allergiziruyuschee of thiamine, pyridoxine a difficult transformation of thiamine in a biologically active form (fosforilirovannuyu).

     It should not be confused in one syringe of vitamin B 1 and penicillin or streptomycin (of antibiotics), and vitamin B 1 and nicotinic acid (vitamin B 1 destruction).

     Method of issuance : thiamine hydrochloride tablets on the 0,002-; 0.005 and 0.01 g; 2, 5% and 5% in injectable solutions to 1 ml; Thiamine - bromide tablets to 0.00258; 0.00645 and 0, 0129 g; 3% and 6% solutions in 1 ml ampoules.

     Storage : in the hermetically ukuporennoy packaging keeps from the world.

     Rp : Tab. Thiamini chloridi 0,002

     N. 50

     D.S. On March 1 pill p Saving the day

     Rp. : Sol. Thiamini chloridi 2, 1 ml 5%

     D.t.d. N. in ampull 10.

     S. He is 1 ml intramuscularly

     Rp. : Sol. Thiamini bromidi 3% 1 ml

     D.t.d. N. in ampull 10.

     S. He is 1 ml intramuscularly

     Beer Yeast dry cleaned (F s x medicinalis, Se revisiae fermentum siccum depuratum). Contain vitamin B 1 (less than 0,014 g / L), vitamin B (less than 0,003 g / l), as well as proteins and other substances.

     Applied for preventive and therapeutic purposes (in the ratio V 1 violations metabolism, decreased food, abrasions, etc.).

     Assign into adults and 2 tea spoons, children and 1 - 2 tea spoons.

     Previously issued pill "Gefefitin" with brewer's yeast, excluded from the range of medicines.

     Solution "Tiodin (Solutio" Thiodinum "). Includes 1 ml thiamine bromide 12, 5 mg and 10 mg of sodium iodide.

     Colorless transparent liquid with low specific smell.

     Antinevralgicheskoe applied as a tool in the lumbar sacral radiculitis, pleksite shoulder, and vospalitelnyhzabolevannyah CNS.

     Enter vnutrnmyshechno (slowly) for 5 to 10 ml / day for 6 to 20 days.

     Possible side effects and contraindications are the same as for preparations containing iodine (see).

     Product : amlulah in 10 ml pack of 10 vials.

     Storage : List B. In the dark place at room temperature.

     Thiamin is part of the series combined polivitaminnmh preparations (see Asnitin, Revit, Dekamevit, Aerovit, Pangeksavit, Kvadevit, Undevit, Komplivit etc.).

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