TETURAM (Teturamum).

     Tetraetiltiuramdisulfid.

     Synonyms : Antabus, Abstinyl, Alcophobin, Antabus, Antaethan, Antaethyl, Anticol, Aversan, Contrapot, Crotenal, Disetil, Disulfiramum, Espenal, Exhorran, Hoca, Noxal, Refusal, Stopethyl, Tetradin and others.

     White poor yellowish greenish white crystalline powder. It is soluble in alcohol, almost nerastvorim in water, acid and alkali.

     Is inside for the treatment of chronic alcoholism, in cases where we can not get the therapeutic effect of other treatments (psychotherapy, vitaminoterapiya, reception apomorfina etc.).

     The operation is based on its ability to specifically affect the exchange of alcohol in the body. Alcohol is oxidation making, passing through phase acetaldehyde and acetic acid. With the atsetaldegidroksidazy, acetaldehyde usually rapidly oxidized.

     Teturam by blocking the enzyme biotransformation of alcohol, leads to a higher concentration of alcohol after receiving acetaldehyde in the blood.

     Current data teturam becomes in the body of N, N-dietilditiokarbaminovuyu acid (DEDKK), and other metabolites, locking metal ions and sulfgidrilnye group of enzymes involved in the removal of alcohol. Accumulation of reception under the influence of alcohol teturama acetaldehyde leads to painful for the patient changes in the body : skin-reddening, feeling warmth in the face and upper torso, a sense of restraint in the chest, difficulty in breathing, noise in the head, heart, a sense of fear, sometimes trembled, etc. . Significant decreases AD.

     Assigning alcohol in the face of teturama generate a negative reflex to the taste and smell of alcohol and the long-term care have full or partial intolerances alcohol.

     Applications may be accompanied teturama pronounced side effects, so it used as a last means.

     Teturamom Before treatment, patients are careful medical examination. Unless contraindicated, the patient explain the meaning of therapy and warned of the dangers of alcohol reception during treatment.

     Teturamom Treatment is carried out under the supervision of a physician. Dose choose individually. Optimal dose (0.25 - 0.5 g / day), usually well transferred and prevented complications even with long-term use. Dose teturama below 0.15 g / day quickly removed from the body and are not required effect - sensitization to alcohol.

     Treatment teturamom usually follows. First teturamalkogolnuyu samples through a 7 - 10 days from the start of treatment. After a morning reception 0.5 - 0.75 g teturama, the patient takes 20 to 30 ml of alcohol, 40% more vodka. Repeat samples in a hospital through a 1 - 2 days out through 3 - 5 days. With a weak reaction in alcohol intake increases in regular samples of 10-20 ml. The maximum dose of vodka 100-120 ml.

     Teturamalkogolnye reaction can proceed in the light, moderate and severe forms.

     In severe reactions of 1 - 1, 5 h (severe headache with a sense raspiraniya and pulsation, a sharp difficulty in breathing, a significant decline in AD, shading consciousness, psychomotor initiation, convulsions) intravenously injecting 15 - 20 ml of 1% aqueous metilenovogo blue, the skin-kordiamin, korazol or joints, intramuscularly, or tsititon lobelin, ephedrine, strychnine; inhalation produce oxygen. Enter intravenous glucose with ascorbic acid. When pain in the heart designate Validol, Corvalol, if necessary, nitroglycerine. At low input AD mezaton or ephedrine. In the case of sudden cardiac oppression of the injected 0.25 - 0.5 ml of 0.05% solution strofantina 20 ml isotonic sodium chloride solution, or 5% glucose solution. When convulsions, intramuscularly 10 mL of 25% magnesium sulfate solution. In severe nausea and vomiting injected 10 ml of 10% solution of calcium chloride or gluconate, provide inside 0,015 g extract lapidary, under the skin impose 0.5 ml 0.1% solution of atropine.

     In the case of the reaction of convulsions, introducing a enema Chloral hydrate (15 to 20 ml water 6% starch solution) or use tranquilizers (see Sibazon, Fenazepam); When psychomotor institute impose intramuscularly 1 - 2 2 ml, 5% solution aminazina.

     A patient must lie in a horizontal position.

     When treating teturamom, especially long, can be various violations of the cardiovascular system, peripheral and central nervous system, the functions of the gastrointestinal tract and liver. Possible allergic reactions (itch, rash), and worsening of past diseases (gastritis, gastric ulcer disease and gastrointestinal cancer, trombophlebitis etc.).

     In some cases, as long reception teturama could experience acute psychosis, which resembles acute alcohol disorder, a severe alcohol or alcohol gallyutsinoz Delirium. Possible shift gallyutsinatornogo syndrome paranoia, paranoia, in shizofrenopodobny etc.

     Absolute contraindications to the use teturama are endocrine diseases (thyrotoxicosis and diabetes mellitus), has expressed cardiosclerosis, cerebral vascular atherosclerosis, and representatives of the outgrowths, via aneurysm, coronary insufficiency, hypertension II and III stages, severe disease brain, heart and disease being decompensation, tuberculosis krovoharkanem with light, fresh tuberculosis infiltration, bronhialnzya asthma, emphysema expressed mild bleeding stomach ulcer, liver and kidney disease; haematopoietic disease, mental illness, brain infections, epilepsy epileptiformnye syndromes, polinevrity, neuritis audible and eye nerves, glaucoma, cancers, pregnancy, Idiosyncrasy to teturamu.

     The relative contraindications are remnants of organic brain damage, age over 60, endarteriit, gastric ulcer disease and gastrointestinal cancer under acute traumatic illness lasting effects after the defeat of the brain infection and stroke, previously deferred teturamovye psychosis.

     Product : pills to 0.15 and 0.25 g, respectively, in packs of 50 and 30 pieces.

     Storage : List B.

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