TESTOSTERONA PROPIONAT (Testosteroni propionas).

      Adrosten-4- ol - 17-b-3 propionat it.

      Synonyms: Agovirin, Androfort, Androlin, Andronate, Homosteron, Malestron, Oreton F Perandren, Sterandryl, Synandrone, Testolutin, Testosterone propionate, Testosteronum propionicum, Testoviron, Virormone and others.

      The white crystalline powder. Almost nerastvorim water, easily soluble in alcohol, soluble in vegetable oils.

      Endogenous Testosterone is a male sex hormone (adrogennym). GOST in male sex gland needed for the development of the genital organs and secondary sexual characteristics in men. Standing a testosterone starts during puberty and continuing until maturity sexual function.

      Current data in the body there androgenov specialized receptors. Circulating testosterone in the blood into body-target in the 5-a-digidrosteron (by the enzyme 5-a-CoA), which binds to receptors androgenov and enters the nucleus of cells. Perhaps bonding and, in some tissues of the testosterone with receptors.

      For use in medical practice are synthetic testosterone by propionat. He possesses biological and medicinal properties of natural hormone, but more slowly absorbed and racks in the body than testosterone. Testosterone propionat parenteral use; Oral it ineffective (quickly destroyed in the liver).

      In addition to the specific actions androgennogo, testosterone, like all Androgens, has implications for the other functions of the body and, in particular, operates on nitrogen and phosphorous exchange. He has anabolic effects and can be regarded as endogenous anabolic hormone. Lack of testosterone in the body (with the lack of sexual development, after castration, etc). Usually involves a violation of protein anabolizma, atrophy of skeletal muscles and increasing deposits in the subcutaneous tissue and internal organs of adipose tissue. Substitution of drugs testosterone can have these changes in the therapeutic effect. Anabolic effect of testosterone is also evident in a variety of pathological conditions involving enhanced dissolution of proteins (chronic infectious diseases, exhaustion, surgery, severe trauma, etc). And a violation of the exchange of calcium and phosphorus (osteoporosis).

      Widespread use of testosterone as a means of preventing its strong androgennoe anabolic effect.

      Currently available drugs that are close to chemical structure to testosterone, but also provide more selective anabolic effects.

      Testosterone propionat appoint mainly men with sexual underdevelopment, functional disorders of the sexual system, klimakteicheskom syndrome, in akromegalii.

      In some cases, testosterone propionat an isolationist improvement in the prostate gland: improving the overall decline urination disorders, etc.

      Introduction propionata testosterone, as well as other androgenov women is braking gonadotropnoy pituitary function, as Acne oppression apparatus and ovary, endometrium atrophy, breast suppression functions. In therapeutic uses testosterone propionat sometimes apply to women with climacteric vascular and neurological disorders in cases where not receive estrogenic drugs (with tumors of the reproductive organs and breast, uterine krovotecheniyah). He also appointed along with radiation therapy in breast cancer and ovarian (usually women aged under 60 years). Old women propionat testosterone can be used with dysfunctional uterine krovotecheniyah.

      Testosterone propionat may also have a positive effect in the early stages of hypertension and strokes angionevroticheskih forms.

      In all cases the drug is used only as a doctor, and during treatment to carefully monitor patients.

      Applied as intramuscular or subcutaneous injection in oil solutions.

      Men with evnuhoidizme, congenital underdevelopment sexual glands and their removal surgically or as a result of trauma, as well as akromegalii appoint 0,025 g (25 mg) daily or 0.05 g (50 mg) in a day or two days. Duration of treatment depends on the effectiveness of therapy and the nature of the disease. Treatment is usually in a long time. After improving clinical impose testosterone propionat in maintaining doses; 0,005 - 0.01 g every day or two or moving to a reception inside metiltestosterona.

      In impotence in connection with a functional deficiency sex glands, nervous exhaustion and overwork, as well as male menopause syndrome appoint 10 mg daily or 25 mg of 2 - 3 times a week for 1 to 2 months.

      In the isolationist prostate gland in the early stages of taking 10 mg a day for a period of 1 to 2 months.

      Women over 45 years of age with dysfunctional uterine krovotecheniyah appoint 0.01 - 0,025 grams (10-25 mg) every other day for 20 to 30 days before the end of bleeding and the emergence atroficheskih cells in the vaginal swabs. Try to delete uterine malignancies.

      In vascular and neurological disorders origin menopause for women and a contraindication to the use of estrogen, testosterone propionat impose on 0.01 g (10 mg) a day, or 0,025 grams (25 mg) two times a week for 2 to 3 weeks. Preferably, in this case, to appoint methyltestosterone.

      For patients with strokes sometimes there is a positive effect in the application of testosterone on the 10.0-12 5 1 mg once a week; With good endurance increases the number of injections to two per week (within 3 to 5 weeks). By the end of treatment and dose to reduce the number of injections. The course of treatment consists of 15 - 20 injection. The positive effects related to the improvement of circulation and exchange in the heart muscle; There are also positive changes in blood lipid ratio, increased lecithin / cholesterol. The best result is when angionevroticheskih forms strokes. When expressed cardiosclerosis hormone treatment ineffective.

      In malignant tumors breast or ovarian testosterone propionat give 0.05 g dose (50 mg) daily for several months, then (depending on the outcome of treatment) dose and reduce long-designate maintaining dose. As addition to surgery or radiation therapy product appoint women to 60 years of age (older women to take estrogen).

      Higher doses intramuscularly to adults: single 0.05 g (1 ml of 5% solution), 0.1 g daily (2 ml of 5% solution).

      When treating testosterone propionatom Valetta and other drugs should be closely monitored patients: high doses can cause increased sexual arousal, the delay of water and salts in the body, dizziness, nausea; Women can be observed phenomenon furry (virilizma): brutalization vote excess hair growth on the face and body, pastoznost person atrophy breast. Overdosing with dismenoree drugs can lead to the end of menstruation.

      When cancer prostate gland Androgenic not receive drugs.

      Product: 1% or 5% solution of oil in capsules to 1 ml.

      Storage: List B. In the dark spot.

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