TERFENADIN (Terfenadine).

     ? - (para-tert Butilfenil) -4 - (oksidifenilmetil) -1 - piperidilbutanol.

     Synonyms : Bronal, Gistadin, Deylert, Karadonel, Rapidal, Riter, Tamagon, Teldan, Teridin, Terfed, Terfena, Tofrin, Treksil, Bronal, Caradonel, Daylert, Histadine, Rapidal, Riter, Seldane, Tamagon, Teridine, Termenadin, Thelldan, Triludan, Tofrin, Toldan, Trexyl and others.

     The white or whitish crystalline powder. Poor soluble in water, easy-to-chloroform, is soluble in alcohol.

     N1- gistaminovyh receptor blockers. Has weak m hoinoblokiruyuschim action.

     There has expressed sedative effect.

     If ingestion is well absorbed (about 70%), C max of 1 hour, not crosses the blood-brain barrier; Under intense biotransformation in the liver with the formation of active metabolite feksofenadina (see), presented with urine and faeces.

     Protivogistaminny effect develops after 1-2 h, reaches 3-4 h, and continued (after a single use), about 12 hours

     Indications for the same as other N1- receptor blockers (allergic rhinitis and conjunctivitis, swelling Kvinke, contact dermatitis, Medicine, allergic reactions to the reception LS, etc.).

     Assign inside adults and children over 12 years of 0.06 g (60 mg), 2 times a day, or one morning, 0.12 g; The maximum daily dose of 0.48 g. Children from 6 to 12 years appoint 0.03 g two times a day.

     In applying the product some have been erythema, Galactorrhea, headache, fatigue, dizziness, drowsiness, dry mucous membranes, nausea, vomiting, appetite increase, the excess dose-zheludochkovye adults (including tachycardia type "pirouette").

     Contraindications : pregnancy and breast-feeding.

     Method of production : tablets of 0.06 and 0.12 g (60 and 129 mg) (N. 10, 20); 0.6% suspension for receiving inside (0.03 g (30 mg) in 1 teaspoonful).

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines