TERBINAFIN (Terbinafine). (E) N (6, 6-Dimethyl-2 gepten-4- inil) - N-methyl naftalinmetanamin.

     Available as hydrochloride.

     Synonyms : Lamizil, Lamizyl (name drug firms' SANDOZ ").

     Anti-drug for oral and exterior. It has a wide range of anti activity. Has fungicidal effect on dermatomitsety, mould fungi, and some dimorfnye mushrooms. Mechanism of action related to suppress the biosynthesis of sterols in cell membranes fungus.

     When local application (in the form of creams) preparation little absorbed and have little systemic effect. In oral application (in the form of tablets), the maximum concentration in plasma is within 2 h; Drug firmly binds to plasma proteins.

     The drug rapidly diffuses through the skin and stored in shared gland. Write cutaneous hall, with the emergence of a relatively high concentration in the hair follicle and hair. In the weeks after the start of penetrating in the drop plates.

     Inside apply terbinafin (in the form of tablets) with fungal skin lesions caused by dermatomitsetami (trihofitiya, mikrosporiya), and yeast skin infections, fungal nail defeat (onihomikozy). Terbinafin also applied for the treatment otrubevidnogo (multicolored) celebrations.

     Assign an adult inside at 0,125 g dose (125 mg), 2 times a day, or 1 0.25 g per day (regardless of meal times). The length of treatment depends on the evidence and the seriousness of the infection. The most common treatment for skin lesions is 2 to 4 weeks, losses nails from 6 weeks to 4 months (and sometimes more long-term).

     The drug is usually well tolerated. In some cases, possible diarrhoeal phenomenon, allergic skin reactions.

     Terbinafin should not appoint pregnancy and breastfeeding, and children (because of the lack of sufficient data). For older patients may experience some disruption liver and kidneys.

     Crem terbinafina (lamizila) External use in fungal skin lesions caused by dermatomitsetami, produced in the skin infection (candidiasis), stripping (otrubevidnom or multicolored). Crem cause thin layer on the surface of the affected and surrounding areas 1 to 2 times a day, a little rubbing.

     Applied depending on the severity of the defeat and efficiency within 1 - 2 - 4 med. Usually treatment effect noted in the first few days.

     Crem well tolerated. In some cases, there hyperemia, itch, a feeling of burning, usually do not require a cessation of treatment.

     Method of production : tablets, containing 0,125 or 0.25 g terbinafina (hydrochloride); 1% ointment in the tubes.

     Storage : pills to keep in the dark spot.

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