SINESTROL (Synoestrolum). meso-3, 4-Di - (para-oksifenil) - hexane.

     Synonyms: Cycloestrol, Dihydrostilbostrul, Estrene, Estronal, Folliplex, Hexanostrol, Hexestrol, Hexestrolum, Hexoestrolum, Hormonestrol, Novostrol, Syntex, Synthovo and others.

     White or white with a slightly yellowish tinge odourless powder. Almost nerastvorim water easily soluble in alcohol, it is difficult to persikovom oil.

     Sinestrol is a synthetic compound-derived stilbena.

     On chemical structure differs from steroid hormones oestrogen, but the biological and curative properties close to him. The group also includes derivatives stilbena dietilstilbestrol, dimestrol and other synthetic estrogenic substances.

     In the early years after these synthetic estrogens have been widely used in medical practice. Later in obtaining more efficient and better transport drugs (norethisterone, etc.) and use sinestrola dietilstilbestrola became more limited.

     Sinestrol on estrogennoy activity amounted estronu: 1 mg sinestrola with 10,000 ED.

     Indications for use in women largely the same as testimony to the application estrona. Sometimes appointed in thyroid cancer and the prostate gland in men.

     Enter intramuscularly, under the skin and inside; Intramuscularly and under the skin in oil production, inside-tablets. Entering into sinestrol quickly absorbed; No breaks in the gastrointestinal tract.

     In gipogenitalizme, congenital amenorrhea and dramatically underdeveloped uterus apply for 0,001 - 0,002 grams (1 to 2 mg) intramuscularly or 0,002 grams (2 mg) daily inside during 4-6 weeks or more. With effect designate then progesterone (5 mg / day intramuscularly) or pregnin (10 mg three times a day inside) during the 6 to 8 days. If necessary courses to therapy again.

     In secondary amenorrhea appoint one-sinestrola 2 mg per day for 15 to 20 days, and then during the 6 - 8-day - or progesterone pregnin in that dose.

     In gipooligomenoree drug appoint 1 mg intramuscularly or inside every day or every other day during the first half mezhmenstrualnogo period; With infertility on the grounds of underdevelopment uterus, and 1 mg intramuscularly, or 1 to 2 mg inside in the first seven-eight days after menstruation; In climacteric disorders appointed interior of 0.0005 - 0.001 g (0.5 to 1 mg). Duration of treatment individualiziruyut (see Estron).

     To reduce breastfeeding women in the postpartum period appoint 0,001 g 2 times a day inside or 1 ml of 0.1% solution of 1 intramuscularly once a day for 2 days; For a complete suppression of lactation on 0,002-0, 003 g / day or 1 ml of 0.1% solution of 2 times a day for 5 to 7 days.

     When breast cancer among women over 60 using 2% solution sinestrola. Enter a daily basis, starting with 1 ml per day, and then gradually increase the daily dose of 5 mL. Through careful observation determine the optimal dose, which imposed for a long time.

     In the case of benign prostate gland impose daily 2 ml of 2% solution (0.04 g) sinestrola within 30 days. During the year, a further 2 - 3 course for 20 days with intervals of 2 to 3 months.

     When prostate gland cancer impose daily 3 - 4 ml 2% solution (0,06 - 0,08 g) intramuscularly within two months, followed by 0.5 to 1 mL of 2% solution in the day intramuscularly or inside. The total dose and duration of treatment depends on the changes in the president demonstrated gland, the presence or absence of metastasis, and the overall level of feminization.

     Sinestrol and other estrogenic drugs (see Fosfestrol, Hlortrianizen) in the treatment of malignant neoplasms are usually used in combination with other methods (surgical treatment, radiation therapy).

     Higher doses sinestrola adults inside: single 0,002 g, 0,004 g daily; In muscle: single 0,002 grams (2 ml of 0.1% solution), a daily 0,003 city

     When treating malignant neoplasms highest single dose of 0.06 g intramuscularly (3 mL of 2% solution), the highest daily dose of 0.1 g (5 mL of 2% solution).

     Sinestrol generally well tolerated by. In some cases, there are nausea, vomiting, dizziness. When you receive large doses can be toxic liver damage, excessive bleeding and endometrial proliferation of women expressed the feminization of men (down sexual function, inflammation milk glands, pigmentation nipples, reducing the size of signs, etc.).

     Sinestrol and its analogues combination of pregnancy and diseases of liver and kidney.

     Method of production: tablets of 0,001 grams (1 mg); 0.1% (1 mg in 1 mL) and 2% (20 mg in 1 mL) oil production in the ampoule and 1 ml; 2% solution used only for treatment patients with malignant tumors.

     Storage: List B. In sheltered from the world scene.

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