SULINDAK (Sulindac). (Z) - 5-methyl Ftor-2- [parameters (metilsulfinil) benziliden] inden-3- acetic acid.

     Synonyms: Klironil, Aflodac, Algocetil, Artribid, Artrobid, Clinoril, lisundac, Dorindac, Flusoril, Lindac, MSD-943, Overpon, Reumofil, Sulindor, Sulinid, Sulreuma, Sutalan and others.

     Sulindac is a non-steroid anti-drug. Provides anti, pain and Analgesic effect. Like other non-steroid anti-drugs inhibited pain Prostaglandin.

     Sulindac quickly absorbed in the employment inside and operates long-term, which allows it to take 1 to 2 times a day.

     In the body Sulindac into two main metabolite; Sulfon and sulphide. The latter is a strong inhibitor of Education Prostaglandin resulting primarily pharmacological effect sulindaka. Thus, Sulindac (sulfoksidnaya form) can be seen as a precursor of active ingredient (<<prolekarstvo>>).

     Provided Sulindac from the body mainly in the form of inactive metabolites and little effect on kidney function.

     Indications for use are the same as for other non-steroid anti-modern drugs: rheumatoid arthritis, osteoarthritis, Ankylosing spondylarthritis periartrity, acute gouty arthritis, lumbago and others.

     Assign Sulindac adults inside in the dose 0.1 - 0.2 g 1 - 2 times a day. Dose choose individually depending on the efficiency and portability products, but not more than 0.4 grams per day. Accepted during the meal.

     The length of treatment depends on the severity of the disease and the effectiveness of therapy. In acute gouty arthritis is usually seven-day course.

     Children older than 2 years Sulindac appoint only acute rheumatoid arthritis. Initial dose is 4, 5 mg / kg / day (2 admission during the meal). If necessary, add to the daily dose of 6 mg / kg (maximum); To achieve positive dose reduced.

     Possible side effects and precautions basically the same as in the treatment of other non-steroid anti-drugs.

     Sulindac contraindications with gastrointestinal krovotecheniyah, propensity for severe allergic reactions related to the admission of other anti-drugs, the development of allergic reactions during a sulindaka in pregnancy.

     Method of production: tablets to 0.1; 0.15, 0.2 and 0.4 was to apply Paediatric also issued suspension containing at 0.01 or 0.04 g (10 or 40 mg drug) 1 ml.

     Storage: List B. In sheltered from the world scene.

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