SULFAZIN (Sulfazinum). 2 - (para-Aminobenzolsulfamido) - Pyrimidine.

     Synonyms : Adiazin, Debenal, Pirimal, Pyrimal, Sulfadiazin, Sulfadiazinum, Sulfapyrimidin, Ultradiazin and others.

     White or white with a yellowish sheen crystalline powder and odourless. Almost nerastvorim in water, very little is soluble in alcohol, in dilute hydrochloric acid and alkali solutions.

     Sulfazin less associated plasma protein slowly out from the body than norsulfazol that ensures higher sulfazina concentrations in the blood and organs.

     Indications for use are the same as for norsulfazola.

     Assign inside. Adult admission for the first offer of 2 g (with heavy infection to 4 g), then, within 1 to 2 days, 1 g at 4 h, and thereafter to 1 g every 6 to 8 hours Treatment hold until the body temperature and in the next three days.

     Children are 0.1 g / kg for the first reception, then 0,025 g / kg (25 mg / kg) every 4 to 6 hours

     In dysentery appointed as sulfadimezin (cm).

     Sulfazin often used in conjunction with other drugs sulfanilamidnymi. Combined with antimalarial (quinine, hloridin etc.) sulfazin used in the treatment of drug-resistant forms of malaria. Sulfazin active against asexually eritrotsitarnyh stages Malaria Plasmodium. As antimalarial drug sulfazin (like other drugs sulfanilamidnym) relatively little activity, it quickly develops resistance Plasmodium. However, admission sulfazina in conjunction with the main antimalarial drugs, the development of drug resistance is slowing and mutually reinforced antimalarial effect.

     Sulfazin relatively rare cause nausea and vomiting, as well as changes in the blood system. Sometimes there hematuria, oliguriya, anuriya.

     When treating sulfazinom must maintain a strong Diurez, drink plenty of alkaline may prevent the development of kidney function.

     Method of issuance : powder; Pills to 0.5 g.

     Storage : List B. In the dark spot.

  6. SULFAZINA SEREBRYANAYA SOL (Sulfazini argenti).

     White kremovatym with nuance melkokristallichesky powder.

     Sulfanilamidnyh different than other drugs in a silver atom molecules, which increases its local anti-- bactericidal effect.

     When the local application of masi wound on the surface of a gradual release of silver ions, which provides long-term effect of the drug.

     Implemented in the form of 1% of masi called ointment <<Sulfargin>> (Ugnuentum <Sulfarginum>). Homogeneous ointment white or white with kremovatym white color with a characteristic smell.

     Assign ointment <Sulfargin> local adults and children over the age of 3 months for the prevention and treatment of wounds and burns investments, trophic ulcers, bedsores. Applied to treat trauma and burn the surface of the 1 st phase of the process of wound exudation weak; Processing of fresh burn surface (to prevent infection); For the treatment of superficial wounds and burns I-III A level in 2 nd and the third phase Wound process trophic ulcers, bedsores, the long-term healing wounds, including wounds cults.

     Ointments cause of skin surface (after surgical treatment and disposal nekrotizirovannyh tissue) thin layer (by the band or open). Fold change 1 - 2 times a day or less. The maximum single dose of treatment duration was 0.3 to 3 weeks.

     Using skin creams can develop allergic reactions related to sulfanilamidnyh drugs, radiation. In rare cases there are short-term phenomenon local irritants (burning pain), which usually runs alone after 5 - 10 minutes.

     In the case of a juvenile over a large surface, should monitor the functions of the kidneys, liver and blood content of standard elements, patients designate a rich alkaline water.

     Ointments <Sulfargin> vaccination premature children, infants and children up to 3 months; In pregnancy; Patients with a marked shortage of glucose-6-fosfatdegidrogenazy and with a heightened sensitivity to sulfanilamidnym drugs. Do not apply ointment for the treatment of deep and festering wounds suffered burns surfaces and rich exudation.

     Product : 1% ointment in tubes of 50 and 180 g and 500 glass banks in the city

     Storage : List B. Banks, in the dark place tubes in normal circumstances.

     A similar ointment (cream) issued abroad (Yugoslavia), entitled "Dermazin (Dermasin) in the box on 50 g and 250 g. of banks

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