SULFASALAZIN (Sulfasalazine). 4-[(2) Piridil- - amidosulfonil] -3, -4 karboksi oksiazobenzol-, or 5 - para-[N - (2-piridil) - sulfamido] - fenilazosalitsilovaya acid.

     Synonyms : Salazosulfapiridin, S. C. 500, Asulfidine, Azopyrine, Salazopyridin, Salazopyrin, Salazosulfapyridine, Salicylazosulfapyridin, Salisulf, S.A.S. 500, Sulfasalazin, Sulphasalazine.

     On chemical structure is azosoedineniem sulfapiridina (sulfidina) with salicylic acid.

     The drug has antibacterial action against diplokokkov, streptococcal gonokokkov, intestinal bacillus. Features of the drug is that it has a pronounced effect in patients treated with nonspecific ulcerative colitis. The mechanism of this action is not fully explored. A role playing ability drugs accumulate in connective tissue (including tissue ulcers) and gradually separated 5-aminosalitsilovuyu acid (see Mesalazin) and sulfapiridin with antibacterial and antiinflammatory properties. The same mechanism of action appears to underlie the therapeutic efficacy in non-ulcerative colitis and salazopiridazina salazodimetoksina.

     The major indication for use salazosulfapiridina (as salazopiridazina and salazodimetoksina) is a non Ulcerative Colitis.

     Assign inside. Recommended Day 1 adult and 1 tablet (0.5 g), 4 times a day (with equal intervals), the 2-day-2 tablets 4 times and in the following days when good endurance preparation for the 3 - 4 4 tablets per day. After stihaniya clinical symptoms of the disease designate support doses (1, 5, 2, 0 g / day) for several months.

     Äåòÿì ñàëàçîñóëüôàïèðèäèí íàçíà÷àþò â ìåíüøèõ äîçàõ; â âîçðàñòå 5 - 7 ëåò - ïî 1/2 - 1 òàáëåòêå (0,25 - 0,5 ã) 3 - 6 ðàç â ñóòêè, ñòàðøå 7 ëåò ïî 1 òàáëåòêå 3 - 6 ðàç â äåíü .

     Salazosulfapiridin also effective in light and medium-heavy form of the disease Krona (granulematozny colitis).

     Recently salazosulfapiridin (sulfasalazin) was used as the reference tool for the treatment of rheumatoid arthritis by using a drug possession immunokorrigiruyuschih properties. Assign 2 -3 g / day (40 mg / kg per day) for 2 to 6 months.

     When treating salazosulfapiridinom may be nausea, vomiting, headache, dizziness. In such cases overturned preparation, but after two days gradually over three days, to raise the dose.

     In the case of allergic reactions (skin deterioration, drug fever), radiation drug use should be discontinued.

     The drug is contraindicated if history expressed MEPhI allergic reactions to sulfanilamidy. Treatment must be conducted under close medical supervision; To systematically monitor blood picture.

     Pills to take at equal intervals of time after eating, heavy zapivat 1 - 2% solution of sodium gidrokarbonata.

     The drug allocated with urine and alkaline (not acidic) reaction stains in the orange-yellow color.

     Product : 0.5 grams of pills in a package of 50 pieces.

     Storage : List B.

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