SULFAPIRIDAZIN (Sulfapyridazinum). 6 - (para-Aminobenzolsulfamido) -3 - metoksipiridazin.

     Synonyms : Kvinoseptil, Kineks, Spofadazin, Sulamin, Altezol, Aseptilex, Davosin, Deposulfal, Depotsulfamid K, Depovernill, Durasulf, Kynex, Lederkyn, Lentosulfa, Lidazin, Longamid, Longisulf, Midicel, Midikel, Myasulf, Neosulfon, Novosulfin, Pirasulfon, Qilnoseptyl , Retasulfin, Spofadazin, Sulamin, Sulfadazina, Sulfadurazin, Sulfalex, Sulfamethopyrazine, Sulfamethoxypyridazine, Sulfamethoxypyridazinum, Sulfurene, Sulphamethoxypiridazin And p.

     White or white to slightly yellowish sheen crystalline powder odourless, bitter taste. Almost nerastvorim water, in little-alcohol, easy-to divorced acid and alkali.

     Sulfapiridazin belongs to the group of long-term sulfanilamidnyh drugs. The drug is rapidly absorbed from the gastrointestinal tract and into the various organs and tissues. After receiving the drug in a single dose of 1 g, therapeutic concentrations in the blood via a one hour and continues throughout the day. The maximum concentration (8-10 mg) is through Z-6 h. Introduction supporting dose (0.5 g) 1 times a day for 7 to 10 days provides therapeutic concentrations in the blood during the course of treatment.

     Slow down sulfapiridazina from the body to a large extent depends on the preparation of renal reabsorption Channel, as well as its ability to communicate intensively proteins (NPZ) plasma. Diluted associated with the protein, not having antibacterial action, the activity is as sulfapiridazina release of a set of proteins.

     Provided sulfapiridazin with urine unchanged (PC-60%) and atsetilirovannoy format (40-70% of the accepted dose). If the kidney function for drug dramatically slowed.

     The drug is effective against gram (pnevmokokki streptococci, enterokokki, staphylococci) and gram (gastric and dysenteric wand, some strains Protea, gonokokk, meningococcal disease) bacteria, virus vysokoaktiven against trachoma, has some simple (toksoplazmy, Plasmodium malaria). It operates on the bacteria resistant to other drugs sulfanilamidnym.

     Sulfapiridazin applied for the treatment of pneumonia, bronchitis, tonzillitov, pharyngitis, otites sores, urinary tract infections investments ways, dysentery, enterokolitov, biliary tract infections, meningitis investments (especially meningococcal and pneumococcal) for the prevention and treatment of investments surgical infections. If necessary, apply also to prevent bacterial infections in viral diseases of the upper respiratory tract. Patients trachoma designate sulfapiridazin sulfapiridazin- and sodium.

     Assign sulfapiridazin inside (tablets). The daily dose given in a time (intervals between consecutive receptions of 24 hours). In one day designated for adults, depending on the severity of illness 1 to 2 g. The next day, give or 0.5 to 1 g and the entire course of treatment in the maintenance dose.

     The average duration of treatment 5 to 7 days. After the normalization of body temperature continues to medication within 2 to 3 days. With good endurance, and a testimony treatment could last up to two weeks.

     In introducing meningitis and severe forms of bacterial infections sulfapiridazina initial dose of 2 g supporting-1 yr

     In light and moderate forms of bacterial infections, and for preventing infections are designated for the first reception of 1 g, and then to 0.5 grams per day.

     Children nominate 25 mg / kg in 1 st day (starting dose), and then to 12, 5 mg / kg (supporting dose).

     Combined with antimalarial drugs, sulfapiridazin used in the treatment of drug-resistant forms of malaria. To this end designate sulfapiridazin with hloridinom (see).

     Sulfapiridazin also used in lechenin leprosy.

     The use of the drug can cause side effects similar to those observed in the treatment of other sulfanilamidami : headache, diarrhoeal phenomenon, skin deterioration, drug fever radiation. These phenomena are relatively rare. If you reduce the dose of adverse events, and, if necessary, stop receiving the drug.

     It should be borne in mind that the slow sulfapiridazina removal from the body and the possibility of cumulation, side effects may be more persistent than sulfanilamidnymi caused a short-acting drugs.

     Kristalluriya is rare (primarily because sulfapiridazin used in small doses).

     Sulfapiridazin contraindications when the history of allergies MEPhI expressed in the application sulfanilamidnyh other drugs.

     Caution should be observed in patients with diseases haematopoietic system, in violation of the functions of the kidneys, liver disease, cardiac decompensation activities.

     When treating sulfapiridazinom should regularly testing of blood and urine.

     Method of issuance : powder; Tablets of 0.5 grams in a package of 10 pieces.

     Storage : List B. In the dark spot.

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