Sulfapiridazin- sodium (sulfapyridazinum-natrium)


SULFAPIRIDAZIN- NATRY (Sulfapyridazinum-natrium). 6 - (para-Aminobenzolsulfamido) -3 - metoksipiridazin- sodium.
     The white or yellowish white with a greenish white crystalline powder. The easily soluble in water, it is difficult to alcohol. Gradually, yellow under the action of sunlight. Slightly gigroskopichen. Aqueous solutions (pH 10% solution of 9, 5-10.5) in sterile + 100 C for 30 min.
     For antimicrobial action with sulfapiridazinu. Good sulfapiridazin- solubility of sodium can apply it locally.
     Applied sulfapiridazin- sodium field in a 10% solution of 7% solution of polyvinyl alcohol and a 20% solution of a 5% solution of polyvinyl alcohol for the treatment of trachoma. For local treatment of purulent infection (inflammation wounds, the long-term healing of ulcers, abscesses, Furuncles, osteomyelitis, etc.) for postoperative wounds to prevent infection using 3 - 5 - 10% solution of distilled water, isotonic sodium chloride solution, or the solution of polyvinyl alcohol.
     When I trachoma being buried in konyunktivalny bag 10% solution of sodium sulfapiridazin- 7% solution of polyvinyl alcohol to 2 drops two times a day (morning and evening) for 30 days. In trachoma II and phase III to the same local treatment and more sulfapiridazin appointed interior. Adults in one-day treatments are 1 - 2 g sulfapiridazina and in the next nine days to 0.5 grams per day. After a 10-day break sulfapiridazina repeat admission to the scheme. Children under the age of 4 years sulfapiridazin appointed interior (one) in 1-day treatment of 0,025 g / kg (25 mg / kg), and in the following days to 0.0125 g / kg (12, 5 mg / kg) a day; from 4 to 12 years in one-day 0.5 g, in the next-to 0.25 g; from 12 to 18 years in one-day 1 g, in the next-to 0.5 g .
     In severe cases, patients trachoma appoint local sulfapiridazin- 20% solution of sodium 5% solution of polyvinyl alcohol while inside in Day 1 of 2 g (adults) sulfapiridazina and in the next few days to 1 year
     If necessary, repeat month course of treatment.
     A local purulent infection drug used for irrigation wounds in the form of dressing and tampons, soaked 3 - 5 - 10% solution. Dressings make or every 1 to 2 days. The duration of treatment with a daily application of 7 days or more (depending on the performance and endurance drug). Once applied to 10 ml of 5% solution of 5 ml or 10% solution (0.5 g product).
     In chronic purulent processes in the lungs and bronchi designate 10% inhalation solution (5 ml of inhalation 2 times a day for 7 to 10 days).
     Local treatment can be combined with the admission sulfapiridazina inside; Take 1 g once in one day, and 0.5 g in the next few days.
     Sulfapiridazin- sodium in the local application of well tolerated.
     Contraindications and precautions are the same as when applying sulfapiridazina inside.
     Product : powder in different packaging for cooking solutions.
     Storage : List B. In dry, the dark spot.
     For the treatment of infectious eye disease (bacterial conjunctivitis, blefarity, keratitis, etc.) sulfapiridazin- sodium was also issued in the form of eye films.
     Films eye with sulfapiridazin- sodium (Membranulae ophthalmice cum Sulfapyridazino-natrio). Homogeneous thin polymer layer is oval-shaped yellow-brown or yellow long 9 mm, a width of 4 to 5 mm, 0.35 mm thick. Each film contains 5 mg of sodium and sulfapiridazin- biorastvorimy polymer.
     The film is in laying down of the century gradually dissolves. It contained sodium sulfapiridazin- has a longer-lasting effect, as applied in solution. The film is a striking one-two times a day.
     Usually films are transferred well. Immediately after laying konyunktivalny film in the bag, should be within a 30 - to 60 keep their eyes in a quiet state, to soak the lachrymal fluid film and its transition to a flexible (soft) state.
     Product : film plastic trophies for their piece extraction and hermetically ukuporennyh glass bottles to 30 pieces and contour packed polyurethane coating for 10 pieces.
     Storage : List B. In dry place.

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